腺苷蛋氨酸联合白蛋白治疗新生儿黄疸的临床疗效及对血清γ-谷氨酰转移酶、胰岛素样生长因子水平的影响

Clinical Efficacy of Adenosylmethionine Combined with Albumin in the Treatment of Neonatal Jaundice and Its Effect on the Serumγ-glutamyltransferase and Insulin-like Growth Factor Levels

目的:探讨腺苷蛋氨酸联合白蛋白治疗新生儿黄疸的临床疗效及对患儿血清γ-谷氨酰转移酶、胰岛素样生长因子水平的影响。方法:选取2017年3月至2019年3月我院收治的203例新生儿黄疸患儿,按照随机数表法分为观察组(n=105)和对照组(n=98)。对照组采用白蛋白治疗,观察组采用腺苷蛋氨酸联合白蛋白治疗。观察及对比两组治疗疗效,黄疸消退时间及黄疸指数水平,治疗前后胆红素各项指标、γ-谷氨酰转移酶、胰岛素样生长因子、转铁蛋白水平的变化。结果:治疗后,观察组总有效率显著高于对照组[92.38%(97/105) vs. 80.61%(79/98)](P<0.05);黄疸消退时间及黄疸指数水平均显著低于对照组[(4.15±0.82) d vs.(5.31±0.92) d,(56.02±7.36)μmol/L vs.(82.86±9.32)μmol/L](P<0.05);间接胆红素、结合胆红素、总胆红素水平均显著低于对照组[(108.75±6.21) d vs.(146.03±7.32) d,(7.49±0.85)μmol/L vs.(9.57±1.02)μmol/L,(117.80±6.52)μmol/L vs.(151.09±8.34)μmol/L](P<0.05);γ-谷氨酰转移酶、胰岛素样生长因子均显著低于对照组[(56.01±6.45) U/L vs.(89.56±10.73) U/L,(19.30±2.17) ng/L vs 26.78±3.67) ng/L](P<0.05);而转铁蛋白水平均显著高于对照组[(1.96±0.27)g/L vs.(1.60±0.24)g/L](P<0.05)。结论:腺苷蛋氨酸联合白蛋白治疗新生儿黄疸的临床疗效显著优于单用白蛋白治疗,其可有效改善患儿的黄疸临床症状,降低血清胆红素、γ-谷氨酰转移酶、胰岛素样生长因子水平。

Objective: To explore the clinical efficacy of adenosylmethionine combined with albumin in the treatment of neonatal jaundice and its effect on the levels of serum γ-glutamyltransferase and insulin-like growth factor in children. Methods: 203 cases of newborns with neonatal jaundice admitted to our hospital from March 2017 to March 2019 were selected, According to the method of random number table, they were divided into the observation group(n=105) and the control group(n=98). The control group was treated with albumin, while the observation group treated with adenosylmethionine combined with albumin. The therapeutic effect, jaundice regression time and jaundice index, changes of bilirubin indexes, γ-glutamyltransferase, insulin-like growth factor and transferrin level before and after treatment were observed and compared between two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group [92.38%(97/105) vs. 80.61%(79/98)](P<0.05). Jaundice regression time and jaundice index were significantly lower than the control group [(4.15±0.82) d vs.(5.31±0.92) d,(56.02±7.36) μmol/L vs.(82.86±9.32) μmol/L](P<0.05). The levels of indirect bilirubin, conjugated bilirubin and total bilirubin were significantly lower than those of the control group [(108.75±6.21) d vs.(146.03±7.32) d,(7.49±0.85) μmol/L vs.(9.57±1.02) μmol/L,(117.80±6.52)μmol/L vs.(151.09±8.34) μmol/L](P<0.05). γ-glutamyltransferase and insulin-like growth factor were significantly lower than those in the control group[(56.01±6.45) U/L vs.(89.56±10.73) U/L,(19.30±2.17) ng/L vs 26.78±3.67]ng/L)(P<0.05). The level of transferrin was significantly higher than that of the control group[(1.96±0.27)g/L vs.(1.60±0.24)g/L](P<0.05). Conclusion: The clinical effect of adenosylmethionine combined with albumin in the treatment of neonatal jaundice is significantly better than that of albumin alone.It can effectively improve the clinical symptoms of jaundice in children, and reduce the levels of serum bilirubin, γ-glutamyltransferase and insulin-like growth factor.