直肠癌根治术治疗直肠癌的疗效及对b FGF、MTL及GDF-15的影响

Curative Efficacy of Radical Surgery for Rectal Cancerin Treatment of Colorectalcancer and Its Effectson b FGF, MTL and GDF-15

目的:探讨直肠癌根治术治疗直肠癌的疗效及对重组人碱性成纤维细胞生长因子(b FGF)、胃动素(MTL)及生长分化因子-15(GDF-15)的影响。方法:选择2016年01月-2019年12月在我院接受治疗的104例直肠癌患者,采用抽签法分为观察组(n=54)和对照组(n=50)。对照组给予传统开腹直肠癌根治术治疗,观察组给予腹腔镜直肠癌根治术治疗。比较手术情况、血清b FGF、MTL、GDF-15、C反应蛋白(CRP)、超氧化物歧化酶(SOD)、丙二醛(MDA)、血管活性肠肽、胃泌素变化情况及并发症发生情况。结果:观察组手术时间显著高于对照组,术中出血量、住院时间、术后排气时间及切口长度均显著低于对照组,差异显著(P<0.05);治疗前,两组血清b FGF、MTL及GDF-15水平无明显差异;治疗后,两组血清b FGF、MTL及GDF-15水平均显著降低,且观察组上述指标均低于对照组(P<0.05);治疗前,两组应激反应水平无明显差异;治疗后,两组血清CRP、MDA水平均显著升高,且观察组上述指标均低于对照组,两组SOD均显著下降,观察组高于对照组(P<0.05);治疗前,两组胃肠激素水平无明显差异;治疗后,两组血管活性肠肽均显著升高,且观察组低于对照组,胃泌素水平均显著降低,且观察组均高于对照组(P<0.05);两组并发症总发生率为5.56%、26.00%,差异具有统计学意义(P<0.05)。结论:在直肠癌患者中应用腹腔镜直肠癌根治术效果显著,可有效改善患者血清b FGF、MTL及GDF-15,且并发症较少。

Objective: To studyCurative efficacy of Radical surgery for rectal cancerin treatment of Colorectalcancerand its effectson Basic fibroblast growth factor(BFGF), motilin(MTL) and growth differentiation factor-15(gdf-15). Methods: 104 patients with rectal cancer who were treated in our hospital from January 2016 to December 2019 were selected and divided into observation group(n=54) and control group(n=50) by drawing lots. The control group was treated with traditional open radical resection of rectal cancer,and the observation group was treated with laparoscopic radical resection of rectal cancer. The operation, serum b FGF, MTL, gdf-15,c-reactive protein(CRP), superoxide dismutase(SOD), malondialdehyde(MDA), vasoactive intestinal peptide, gastrin and complications were compared. Results: The operative time of the observation group was significantly higher than that of the control group, and the intraoperative blood loss, hospital stay, postoperative exhaust time and incision length were significantly lower than those of the control group, with significant differences(P<0.05). Before treatment, there was no significant difference in serum levels of BGF, MTL and gdf-15 between the two groups. After treatment, serum levels of BGF, MTL and gdf-15 in the two groups were significantly reduced, and the above indicators in the observation group were lower than those in the control group(P<0.05). Before treatment, there was no significant difference in stress response between the two groups. After treatment, serum CRP and MDA levels in the two groups were significantly increased, and the above indexes in the observation group were lower than those in the control group, while SOD levels in the two groups were significantly decreased, while those in the observation group were higher than those in the control group(P<0.05). Before treatment, there was no significant difference in gastrointestinal hormone levels between the two groups. After treatment, vasoactive intestinal peptides were significantly increased in both groups, lower in the observation group than in the control group, and gastrin levels were significantly reduced in the observation group, and higher in the observation group than in the control group(P<0.05). The total incidence of complications in the two groups was 5.56% and 26.00%, and the difference was statistically significant(P<0.05). Conclusion:Laparoscopic radical resection of rectal cancer in patients with rectal cancer has a significant effect, which can effectively improve the patients’ serum serum b FGF, MTL and df-15, with fewer complications.