济南地区产妇与其新生儿百日咳抗体水平调查

The level of antibodies to Bordetella pertussis among pregnant women and their newborns in Jinan area

目的了解不同年龄产妇及其新生儿的百日咳抗体水平。方法以酶联免疫法检测100对不同年龄的健康产妇外周血及其所产新生儿的脐带血(新生儿端)的百日咳抗体水平。结果20世纪70年代、80年代和90年代出生产妇的百日咳IgG抗体中位水平为7.99 IU/mL、5.00 IU/mL和5.71 IU/mL,三组间的差异有统计学意义(P<0.05)。产妇血清百日咳IgG抗体阴性占97%,新生儿百日咳IgG抗体阴性占92%。产妇的血清百日咳IgG抗体与其对应的新生儿脐带血的百日咳IgG抗体水平呈正相关(r=0.76,P<0.001)。结论目前产妇的百日咳抗体不能保护产妇免于百日咳感染,同时胎传抗体的保护作用弱,可以考虑进一步调整免疫接种策略以预防百日咳。

Objective To explore the pertussis antibody levels of mothers of different ages and their newborns.Methods Enzyme-linked immunosorbent assay was used to detect the pertussis antibody levels in the peripheral blood of 100 pairs of healthy mothers of different ages and the umbilical cord blood(newborn side)of their newborns.Results The median levels of pertussis IgG antibodies in women born in the 1970 s,1980 s and 1990 s were 7.99 IU/mL,5.00 IU/mL and 5.71 IU/mL,respectively,and the difference among the three groups were statistically significant(P<0.05).Serum pertussis IgG antibody was negative in 97%of the mothers and negative in 92%of the newborns.There was a positive correlation between maternal serum pertussis IgG antibody levels and neonatal umbilical cord blood pertussis IgG antibody levels(r=0.76,P<0.001).Conclusion Current maternal pertussis antibodies cannot protect women from pertussis infection,and the protective effect of fetal antibodies obtained from the mother is weak.Further adjustment of immunization strategies to prevent pertussis may be considered.