腹腔镜手术联合靶向治疗胃肠间质瘤的临床疗效分析

Clinical Analysis of Gastrointestinal Stromal Tumor with Laparoscopic Surgery Combined with Targeted Therapy

目的探讨腹腔镜手术联合靶向治疗胃肠间质瘤的临床疗效。方法将2017年8月—2018年6月该院收治的28例胃肠间质瘤患者作为研究对象,采取随机抽签法将其分为对照组(n=14)与试验组(n=14),对照组施以常规的开腹手术联合靶向治疗方式,试验组施以腹腔镜手术联合靶向治疗方式,患者的手术时间、术中出血量、术后腹腔引流量、术后排气时间、术后住院时间、术后并发症发生情况、临床治疗效果、复发与转移情况进行观察。结果①对照组患者的手术时间、术中出血量、术后腹腔引流量、术后排气时间、术后住院时间分别为(89.56±20.35)min、(132.51±35.05)mL、(156.71±42.49)mL、(3.06±0.77)d、(8.45±1.31)d,试验组患者的手术时间、术中出血量、术后腹腔引流量、术后排气时间、术后住院时间分别为(112.47±30.27)min、(86.28±19.57)mL、(104.82±35.01)mL、(2.15±0.51)d、(7.26±1.07)d,两组患者之间的差异有统计学意义(t=2.350、4.309、3.527、3.687、2.632,P=0.027、<0.001、0.002、0.001、0.014)。②对照组患者的并发症例数为6例,并发率为42.86%,试验组患者的并发症例数为1例,并发率为7.14%,组间差异有统计学意义(χ^2=4.762,P=0.029)。③试验组患者的治疗有效例数为13例,有效率为92.86%,对照组患者的治疗有效例数为8例,有效率为57.14%,组间差异有统计学意义(χ^2=4.762,P=0.029)。④对照组患者的转移率为14.26%,试验组患者的转移率为7.14%,差异有统计学意义(χ^2=0.373,P=0.541)。结论腹腔镜手术联合靶向治疗胃肠间质瘤具有显著的临床疗效。

Objective To explore the clinical efficacy of laparoscopic surgery combined with targeted therapy for gastrointestinal stromal tumors. Methods Twenty-eight patients with gastrointestinal stromal tumors admitted to the hospital from August 2017 to June 2018 were taken as the research objects, and they were divided into a control group(n=14) and a experimental group(n=14) by random drawing, the control group received conventional open surgery combined with targeted therapy, and the experimental group received la-paroscopic surgery combined with targeted therapy. The patient’s operating time, intraoperative blood loss, postoperative abdominal drainage, postoperative exhaust time, postoperative hospital stay, postoperative complications, clinical treatment effects, recurrence and metastasis were observed. Results 1. The operation time, intraoperative blood loss, postoperative abdominal drainage, postoperative ex-haust time, and postoperative hospital stay of the control group were respectively(89.56 ± 20.35)min,(132.51±35.05)mL,(156.71±42.49)mL,(3.06±0.77)d,(8.45±1.31)d. The operation time, intraoperative blood loss, postoperative abdominal drainage, postoperative exhaust time, and postoperative hospital stay of the experimental group were(112.47 ±30.27)min,(86.28 ±19.57)mL,(104.82 ±35.01)m L,(2.15±0.51)d,(7.26±1.07)d, there were significant differences between the two groups of patients(t=2.350, 4.309, 3.527, 3.687,2.632, P=0.027, <0.001, 0.002, 0.001, 0.014). 2.The number of concurrent patients in the control group was 6 and the concurrency rate was 42.86%, and the number of patients in the experimental group was 1 concurrency, and the concurrency rate was 7.14%, the difference was statistically significant(χ~2=4.762, P=0.029). 3.The effective number of patients in the experimental group was 13 cases,and the effective rate was 92.86%, and the number of patients in the control group was 8 cases and the effective rate was 57.14%, the difference was statistically significant(χ~2=4.762, P=0.029). 4.The metastasis rate of patients in the control group was 14.26%, and that of patients in the experimental group was 7.14%,the difference was statistically significant(χ~2=0.373, P=0.541). Conclusion Laparoscopic surgery combined with targeted therapy for gastrointestinal stromal tumors has a significant clinical effect.