美沙拉嗪颗粒联合枯草杆菌二联活菌肠溶胶囊治疗溃疡性结肠炎临床分析

Clinical Analysis of Mesalazine Granules Combined with Bacillus Subtilis Double Live Bacteria Enteric-Coated Capsules in the Treatment of Ulcerative Colitis

目的探究美沙拉嗪颗粒联合枯草杆菌二联活菌肠溶胶囊治疗溃疡性结肠炎的临床效果。方法将2017年10月—2019年10月期间该院收治的160例溃疡性结肠炎患者作为研究对象,并将其随机分至两组,对照组患者采用口服美沙拉嗪颗粒进行治疗,研究组患者在口服美沙拉嗪颗粒的基础上,同时联合枯草杆菌二联活菌肠溶胶囊进行治疗,治疗结束后,对两组患者治疗效果、治疗前后症状积分及不良反应发生情况进行调查。结果研究组患者治疗总有效率(96.25%)显著高于对照组患(82.50%),差异有统计学意义(χ^2=10.320,P<0.05);治疗前两组患者症状积分差异无统计学意义(t=1.030,P>0.05),治疗后两组患者症状积分均有降低,但研究组患者症状积分降低幅度更为显著,差异有统计学意义(t=6.630,P<0.05);研究组患者不良反应发生率(11.25%)与对照组患者不良反应发生率(12.50%)差异无统计学意义(χ^2=0.980,P>0.05)。结论将美沙拉嗪颗粒联合枯草杆菌二联活菌肠溶胶囊应用于溃疡性结肠炎的临床治疗当中,可有效改善患者临床症状,且具有较高的安全性,效果显著,值得推广。

Objective To explore the clinical effect of mesalazine granules combined with Bacillus subtilis double live bacteria enteric-coated capsules in the treatment of ulcerative colitis.Methods 160 patients with ulcerative colitis admitted to the hospital from October 2017 to October 2019 were taken as the research subjects,and they were randomly divided into two groups.The control group was treated with oral mesalazine particles.Patients in the two groups were treated with mesalazine granules orally and combined with Bacillus subtilis double live bacteria enteric-coated capsules.After the treatment,the treatment effect,symptom scores before and after treatment and the occurrence of adverse reactions were investigated.Results The total effective rate(96.25%)of the study group were significantly higher than that of the control group(82.50%),the difference was statistically significant(χ^2=10.320,P<0.05);there was no statistically significant difference in the symptom scores of the two groups before treatment(t=1.030,P>0.05),and the symptom scores of the two groups were reduced after treatment,but the reduction of symptom scores in the study group was more significant,and the difference was statistically significant(t=6.630,P<0.05);There was no statistically difference in the incidence of adverse reactions of the study group(11.25%)and the control group(12.50%)(χ^2=0.980,P>0.05).Conclusion The application of mesalazine granules combined with Bacillus subtilis double live bacteria enteric-coated capsules in the clinical treatment of ulcerative colitis can effectively improve the clinical symptoms of patients,and has high safety,significant effects,and is worthy of promotion.