慢性鼻窦炎鼻息肉患者术后使用糖皮质激素对复发率和不良反应的研究

Study on the Recurrence Rate and Adverse Reactions of Glucocorticoids in Patients with Chronic Sinusitis and Nasal Polyps

目的研究慢性鼻窦炎鼻息肉患者术后给予患者口服糖皮质激素对复发率和不良反应的影响。方法于2017年5月—2019年5月选择该院收治的100例慢性鼻窦炎鼻息肉患者,采用随机数字表法将其分为实验组与参照组,各为50例。其中参照组行鼻内镜下鼻窦开放术联合鼻内切除术,实验组在参照组基础上术后给予患者口服糖皮质激素,对比两组患者治疗前后白介素水平、不良反应及复发情况。结果慢性鼻窦炎鼻息肉患者治疗前白介素水平具有一致性(P>0.05),实验组治疗后白介素4、白介素17、白介素33水平低于参照组,差异有统计学意义(P<0.05)。实验组与参照组慢性鼻窦炎鼻息肉患者水肿、腹泻、皮疹、肝功能异常不良反应发生率分别为8.00%、4.00%,具有一致性(χ%2=0.709,P>0.05),实验组慢性鼻窦炎鼻息肉复发率(4.00%)低于参照组(18.00%),差异有统计学意义(χ2=5.005,P<0.05)。结论慢性鼻窦炎鼻息肉患者术后应用糖皮质激素效果确切,能够有效降低患者复发比例,且药物不良反应发生率较低。

Objective To study the effects of oral glucocorticoids on the recurrence rate and adverse reactions of patients with chronic sinusitis and nasal polyps after surgery.Methods A total of 100 patients with chronic sinusitis and nasal polyps in the hospital from May 2017 to May 2019 were selected.They were divided into the experimental group and the reference group by a random number table method,each with a value of 50 cases.The reference group underwent endoscopic sinus surgery combined with intranasal resection,and the experimental group was given oral glucocorticoids after the operation on the basis of the reference group.The interleukin levels,adverse reactions and recurrences of the two groups were compared before and after treatment.Results The interleukin levels of patients with chronic sinusitis and nasal polyps were consistent before treatment(P>0.05).After treatment,the levels of interleukin 4,interleukin 17,and interleukin 33 in the experimental group were lower than those of the reference group,and there were statistically significant differences between the groups(P<0.05).The incidence of edema,diarrhea,rash,and liver function abnormalities in the experimental group and the reference group of patients with chronic sinusitis and nasal polyps were 8.00%and 4.00%,respectively,which were consistent(χ^2=0.709,P>0.05),the recurrence rate of chronic sinusitis and nasal polyps in the experimental group(4.00%)is lower than the reference group(18.00%),there was statistically significant difference between the groups(χ^2=5.005,P<0.05).Conclusion The effect of glucocorticoids on patients with chronic sinusitis and nasal polyps after surgery is definite,which can effectively reduce the recurrence rate of patients and the incidence of adverse drug reactions is low.