盐酸拉贝洛尔辅助治疗重度妊娠期高血压患者临床疗效及尿蛋白指标影响

The Clinical Efficacy and Urinary Protein Index of the Adjuvant Treatment of Labetalol Hydrochloride in Severe Hypertensive Pregnancy

目的分析重度妊娠期高血压患者采用盐酸拉贝洛尔辅助治疗作用。方法选择在2018年4月—2019年4月该院进行重度妊娠期高血压治疗的86例患者为研究样本,采取随机数字排列表法将其分成均43例的常规组以及实验组。予以常规组患者硫酸镁治疗,予以实验组患者硫酸镁以及拉贝洛尔治疗。对比两组用药前后收缩压、舒张压以及24 h尿蛋白水平,观察每组患者不良反应出现情况。结果两组患者用药前在收缩压以及舒张压方面比较差异无统计学意义(P>0.05),用药前后两组组内收缩压以及舒张压比较差异有统计学意义(P<0.05),并且用药后实验组患者收缩压(136.52±9.11)mmHg、舒张压(88.25±8.87)mmHg水平均低于常规组收缩压(166.86±9.87)mmHg、舒张压(109.23±9.06)mmHg(t=14.812、10.851,P<0.05)。两组患者用药前后24 h尿蛋白水平比较差异无统计学意义(P>0.05),用药前后两组组内24 h尿蛋白水平比较差异有统计学意义(P<0.05),并且用药后实验组患者24 h尿蛋白水平(1.82±0.26)g低于常规组(2.59±0.30)g(t=12.719,P<0.05)。实验组与常规组不良反应总出现率分别是2.33%、13.95%(χ^2=3.888,P<0.05)。结论重度妊娠期高血压患者采用拉贝洛尔辅助治疗可有效改善患者收缩压、舒张压以及24 h尿蛋白水平,并且不良反应较少,安全性较高,具有一定的临床应用价值。

Objective To analyze the adjuvant treatment effect of labetalol hydrochloride in patients with severe hypertension during pregnancy.Methods Eighty-six patients who were treated for severe pregnancy-induced hypertension in the hospital were selected as the study samples.The treatment time was between April 2018 and April 2019.Random number ranking method was adopted to divide them into two groups of 43 cases each(routine group and experimental group).Patients in the conventional group were treated with magnesium sulfate,and patients in the experimental group were treated with magnesium sulfate and labetalol.The systolic blood pressure,diastolic blood pressure,and 24-hour urine protein levels before and after the two groups were compared,and the adverse reactions of each group were observed.Results There was no statistically significant difference in systolic and diastolic blood pressure between the two groups of patients before medication(P>0.05),and the difference in systolic and diastolic blood pressure between the two groups before and after medication was statistically significant(P<0.05),and medication The systolic blood pressure(136.52±9.11)mmHg and diastolic blood pressure(88.25±8.87)mmHg levels of the patients in the experimental group were lower than those in the conventional group(166.86±9.87)mmHg and diastolic blood pressure(109.23±9.06)mmHg(t=14.812,10.851,P<0.05).There was no statistically significant difference in the 24-hour urine protein levels between the two groups of patients before and after medication(P>0.05).The difference in the 24-hour urine protein levels between the two groups before and after medication was statistically significant(P<0.05),and the experiment after medication The 24-hour urine protein level(1.82±0.26)g of patients in the group was lower than that of the routine group(2.59±0.30)g(t=12.719,P<0.05).The total incidence of adverse reactions in the experimental group and the routine group were 2.33%and 13.95%respectively(χ^2=3.888,P<0.05).Conclusion The adjuvant treatment of labetalol in patients with severe hypertension during pregnancy can effectively improve the patient's systolic blood pressure,diastolic blood pressure,and 24-hour urine protein levels,with fewer adverse reactions,high safety,and certain clinical application value.