厦门市海沧地区围生期孕妇B群链球菌感染及药敏情况分析

Analysis of Infection and Drug Sensitivity of Group B Streptococcu Infection in Pregnant Women in Haicang District of Xiamen

目的:分析厦门市海沧地区围生期孕妇B群链球菌(GBS)感染及其药物敏感情况,为临床应对围生期孕妇GBS感染的诊断和治疗提供客观依据。方法:采集2017年1月-2018年12月于本院妇产科就诊的5470例孕妇送检的阴道分泌物及肛周拭子样本进行细菌培养、鉴定及药敏试验。分析5470例围生期孕妇GBS感染情况,不同年龄段及不同样本GBS阳性检出情况,分析阳性GBS菌株药敏情况。结果:5470例围生期孕妇中,GBS感染阳性220例,GBS感染率为4.02%。41-45岁阳性检出率最高(10.38%),其次为26-30岁(4.47%)、31-35岁(3.85%)、36-40岁(2.56%)。41-45岁孕妇GBS阳性检出率高于其他年龄段(P<0.05)。阴道分泌物阳性136例,占比2.49%,肛周拭子阳性131例,占比2.39%;阴道分泌物与肛周拭子阳性检出率比较,差异无统计学意义(P>0.05)。267株GBS阳性菌株对青霉素、氨苄西林、头孢曲松、头孢噻肟、头孢吡肟敏感率最高,均为100%,其次为左氧氟沙星(80.5%)和奎奴普丁/达福汀(74.9%);对红霉素(68.2%)、克林霉素(71.5%)、四环素(72.3%)耐药性较高。结论:厦门市海沧地区21-45岁围生期孕妇GBS感染率为4.02%,以41-45岁感染率最高。GBS对青霉素及头孢菌素类抗菌药物敏感率最高,临床治疗可首选青霉素或头孢菌素抗菌药物。

Objective:To analyze the infection and drug sensitivity of group B streptococcus(GBS)in perinatal pregnant women in Haicang District of Xiamen,so as to provide an objective basis for the diagnosis and treatment of GBS infection in perinatal pregnant women.Method:Vaginal secretions and perianal swabs were collected from 5470 pregnant women in our hospital from January 2017 to December 2018 for bacterial culture,identification and drug sensitivity test.GBS infection of 5470 perinatal pregnant women was analyzed.The positive detection of GBS in different age groups and samples was analyzed.The drug sensitivity of positive GBS strains was analyzed.Result:Among 5470 cases of perinatal pregnant women,220 cases were positive for GBS infection,and the infection rate of GBS was 4.02%.The positive rate of 41-45 years old(10.38%)was the highest,followed by 26-30 years old(4.47%),31-35 years old(3.85%),36-40 years old(2.56%).The positive rate of GBS in pregnant women aged 41-45 was higher than those in other age groups(P<0.05).There were 136 cases of vaginal secretion positive,accounting for 2.49%,131 cases of perianal swab positive,accounting for 2.39%.There was no significant difference in the positive detection rate between vaginal secretion and perianal swab(P>0.05).267 GBS positive strains were most sensitive to Penicillin,Ampicillin,Ceftriaxone,Cefotaxime and Cefepime,all of which were 100%,followed by Levofloxacin(80.5%)and Quinuputin/Daphnetin(74.9%).The drug resistance to Erythromycin(68.2%),Clindamycin(71.5%)and Tetracycline(72.3%)was higher.Conclusion:In Haicang area of Xiamen city,the infection rate of GBS in 21-45 years old of perinatal pregnant women was 4.02%,and the rate of GBS in 41-45 years old of perinatal pregnant women was the highest.GBS has the highest sensitivity to Penicillin and Cephalosporin antibiotics,and Penicillin or Cephalosporin antibiotics can be the first choice for clinical treatment.