血红蛋白电泳结合血常规检验筛查产前地中海贫血的临床价值

Clinical value of hemoglobin electrophoresis combined with routine blood test in screening thalassemia before delivery

目的将血红蛋白电泳结合血常规检验用于对产前地中海贫血的筛查,并对其应用价值进行分析。方法选取2018年1月至2018年12月在深圳市宝安区石岩人民医院经基因检查确诊为地中海贫血的120例孕妇作为观察组,择取同期该院收治的120例非地中海贫血孕妇作为对照组。两组行血红蛋白(Hb)电泳、血常规检验,评价血红蛋白电泳结合血常规检验对产前地中海贫血的敏感性及特异性。结果血常规、Hb电泳及血常规与Hb电泳联合检验地中海贫血的敏感性分别为88.67%、75.83%和98.33%,特异性分别为52.50%、67.50%和90.00%。血常规与Hb电泳联合检验其敏感性、特异性较单项检验检验相对更高(P<0.05)。结论血常规检验与Hb电泳在诊断孕妇地中海贫血中应用价值较高,将两者联合用于产前地中海贫血筛查中,有利于提升诊断的敏感性及特异性,值得推广应用。

【Objective】To analyze the application value of hemoglobin electrophoresis combined with routine blood test in prenatal thalassemia screening.【Methods】From January to December 2018,120 pregnant women diagnosed as thalassemia by genetic examination were selected as the observation group,and 120 non-thalassemia pregnant women were selected as the control group.Hemoglobin electrophoresis and blood routine test were performed in both groups to evaluate the sensitivity and specificity of hemoglobin electrophoresis combined with blood routine test for prenatal thalassemia.【Results】The sensitivity of blood routine test,Hb electrophoresis,blood routine test and Hb electrophoresis were 88.67%,75.83%,98.33%and the specificity were 52.50%,67.50%and 90.00%respectively.The sensitivity and specificity of blood routine test and Hb electrophoresis were higher than that of single test(P<0.05).【Conclusion】The blood routine test and hemoglobin electrophoresis are of high value in the diagnosis of thalassemia in pregnant women.The combination of the two methods in prenatal thalassemia screening can improve the sensitivity and specificity of diagnosis,which is worthy of application and promotion.