妊娠晚期孕妇维生素A含量与妊娠期高血压疾病和分娩结局的关系

Relationship between vitamin A content in pregnant women and HDCP and delivery outcomes in late pregnancy

目的研究妊娠晚期孕妇维生素A含量与妊娠期高血压疾病(HDCP)和分娩结局之间的关系。方法选取广州市番禺区何贤纪念医院2016年10月至2019年10月间收治的90例妊娠晚期孕妇为研究对象,根据体内维生素A含量,将其分为观察组和对照组,观察组为60例缺乏维生素A的孕妇,对照组为30例维生素A正常孕妇。比较两组孕妇的平均血压值以及高血压的比例,并采用Logistic回归分析探讨孕妇体内的维生素A含量与HDCP的发生的相关性,比较两组孕妇的分娩结局。结果观察组产妇的收缩压、舒张压水平均明显高于对照组(P<0.05),发生HDCP的可能性大于对照组(χ2=8.53,P=0.00),Logistic回归分析显示,孕妇体内的维生素A含量与发生HDCP有着密切相关性(P=0.00,r=-0.429),维生素A含量升高与HDCP的发生呈现负相关性。观察组孕妇发生胎膜早破、产后出血、剖宫产、羊水过多等不良妊娠结局几率明显高于对照组(P<0.05),阴道分娩率明显低于对照组(P<0.05)。结论体内维生素A含量下降的妊娠晚期孕妇普遍血压升高明显,影响分娩结局,且孕妇体内的维生素A含量下降与妊娠期高血压的发生呈正相关性。

【Objective】To study the relationship between vitamin A levels in pregnant women in late pregnancy and hypertensive disorder complicating pregnancy(HDCP)and delivery outcomes.【Methods】Ninety pregnant women with advanced pregnancy admitted to our hospital from October 2016 to October 2019 were selected as subjects.According to the vitamin A content in the body,they were divided into observation group and control group.The observation group was 60 pregnant women lacking vitamin A.The control group was 30 normal pregnant women with vitamin A.The average blood pressure and the proportion of hypertension were compared between the two groups.Logistic regression analysis was used to analyze the correlation between vitamin A content and HDCP in pregnant women,and the outcomes of the two groups of pregnant women were compared.【Results】The systolic blood pressure and diastolic blood pressure of the observation group were significantly higher than those of the control group(P<0.05),and the possibility of HDCP was greater than that of the control group(χ2=8.53,P=0.00).Logistic regression analysis showed that the vitamin A content in pregnant women was closely related with the occurrence of HDCP(P=0.00,r=-0.429),and the increase of vitamin A content was negatively correlated with the occurrence of HDCP.The incidence of adverse pregnancy outcomes such as premature rupture of membranes,postpartum hemorrhage,cesarean section,and polyhydramnios was significantly higher in the observation group than in the control group(P<0.05).The vaginal delivery rate was significantly lower in the observation group than in the control group(P<0.05).【Conclusion】Pregnant women in the third trimester of pregnancy with decreased vitamin A levels have a significant increase in blood pressure,which affects the outcome of childbirth,and the decrease in vitamin A content in pregnant women is positively correlated with the occurrence of hypertensive disorder in pregnancy.