低分子肝素钠联合地屈孕酮对先兆流产患者保胎成功率及新生儿结局的影响

Effect of low molecular weight heparin sodium combined with dydrogesterone on success rate of fetuses and neonatal outcome in patients with threatened abortion

目的探讨低分子肝素钠联合地屈孕酮对先兆流产患者保胎成功率及新生儿结局的影响。方法选取宝丰县人民医院2017年11月至2018年11月收治的66例先兆流产患者,按随机数字表法分为观察组和对照组,各33例。对照组给予地屈孕酮治疗,观察组在对照组的基础上联合使用低分子肝素钠治疗,比较两组患者保胎成功率及新生儿结局。结果治疗后,观察组患者的保胎成功率显著高于对照组(P<0.05);观察组新生儿不良结局的发生率明显低于对照组(P<0.05)。结论采用低分子肝素钠联合地屈孕酮对先兆流产患者进行治疗,可有效提高保胎成功率,降低新生儿不良结局的发生率。

【Objective】To investigate the effect of low molecular weight heparin sodium combined with dydrogesterone on the success rate of pregnancy preservation and neonatal outcomes in threatened abortion patients.【Methods】Sixty cases of threatened abortion in our hospital from November 2017 to November 2018 were divided into observation group and control group according to random number table method,33 cases in each group.The control group was treated with dydrogesterone,while the observation group was treated with low molecular weight heparin sodium on the basis of the control group.The success rate of fetal protection and neonatal outcomes were compared between the two groups.【Results】After treatment,the success rate of fetal protection in the observation group was significantly higher than that in the control group(P<0.05),and the incidence of adverse neonatal outcomes in the observation group was significantly lower than that in the control group(P<0.05).【Conclusion】Low molecular weight heparin sodium combined with dydrogesterone can effectively improve the success rate of fetal protection and reduce the incidence of adverse neonatal outcomes.