布地奈德雾化吸入与干扰素联合对小儿病毒性肺炎血清IL-6的影响研究

Study on the Effect of Budesonide Nebulization Combined with Interferon on Serum IL-6 in Children with Viral Pneumonia

目的研究布地奈德雾化吸入与干扰素联合对小儿病毒性肺炎血清IL-6的影响。方法方便选取该院自2017年1月—2019年12月儿科住院的病毒性肺炎患儿104例,采用数字表随机法随机分成两组,对照组(n=52)应用常规治疗+利巴韦林雾化吸入进行治疗,观察组(n=52)应用常规治疗+布地奈德雾化吸入+干扰素进行治疗,比较两组临床效果。结果观察组患儿治疗总有效率(94.23%)高于对照组(73.08%),差异有统计学意义(χ^2=8.508,P<0.05)。两组患儿治疗前血清IL-6水平比较,差异无统计学意义(t=0.208,P>0.05)。两组患儿治疗7 d后血清IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组用药不良反应率3.85%,对照组用药不良反应率1.92%,两组患儿用药不良反应率比较,差异无统计学意义(χ^2=0.574,P>0.05)。结论布地奈德雾化吸入与干扰素联合可降低小儿病毒性肺炎血清IL-6水平,是治疗病毒性肺炎的有效药物。

Objective To study the effect of budesonide nebulized inhalation combined with interferon on serum IL-6 in children with viral pneumonia. Methods A total of 104 children with viral pneumonia who were hospitalized in the hospital from January 2017 to December 2019 were convenient selected and randomly divided into two groups by number table. The control group(n=52) was treated with conventional treatment + ribavirin nebulized inhalation was used for treatment. The observation group(n=52) was treated with conventional treatment + budesonide nebulized inhalation + interferon to compare the clinical effects of the two groups. Results The total effective rate of treatment of children in the observation group(94.23%) was higher than that of the control group(73.08%), and the difference was statistically significant(χ^2=8.508, P<0.05). There was no statistically significant difference in serum IL-6 levels between the two groups of children before treatment(t=0.208, P>0.05). Serum IL-6 levels of the two groups of children after 7 d of treatment were lower than before treatment, and the observation group was lower than that of the control group, the difference was statistically significant(P<0.05). The adverse reaction rate of the observation group was 3.85%, and that of the control group was 1.92%. There was no statistically significant difference in the adverse reaction rate of the two groups of children(χ^2=0.574, P>0.05). Conclusion The combination of budesonide nebulized inhalation and interferon can reduce the level of serum IL-6 in children with viral pneumonia and is an effective drug for the treatment of viral pneumonia.