奥曲肽对急性胰腺炎患者血生化相关指标与胃肠动力的影响

Effects of Octreotide on Chemistry-related Indexes and Gastrointestinal Motility in Patients with Acute Pancreatitis

目的探讨急性胰腺炎患者行奥曲肽治疗的临床有效价值。方法纳入该院于2018年3月—2019年10月阶段收治的急性胰腺炎患者100例,以随机数字表法分为观察组和对照组,以均分原则50:50选入两组中。对照组实施常规治疗,观察组实施奥曲肽治疗。记录2组临床症状、体征、血尿淀粉酶恢复用时、治疗前后生化指标以及血生化水平。结果观察组呕吐改善84.00%,腹胀好转88.00%以及肛门排气94.00%均高于对照组(66.00%、70.00%、80.00%),差异有统计学意义(χ^2=4.320,P=0.038;χ^2=4.882,P=0.027;χ^2=4.332,P=0.037);观察组腹部疼痛消失时间(3.41±1.03)d,肠鸣音恢复时间(3.35±0.68)d,体温(2.92±0.88)d,尿淀粉酶(3.70±1.56)d,血淀粉酶(5.28±1.14)d恢复时间短于对照组(4.66±1.31)d、(5.12±1.20)d、(4.34±1.12)d、(5.90±1.93)d、(8.44±1.86)d(t=5.304,P<0.001;t=9.074,P<0.001;t=7.049,P<0.001;t=6.268,P<0.001;t=10.242,P<0.001);观察组治疗前尿淀粉酶(2 086.56±1050.23)IU/L、血淀粉酶(512.12±175.41)IU/L水平和对照组(2 043.25±1 023.36)IU/L、(504.21±164.85)IU/L对比差异无统计学意义(t=0.209,P=0.835;t=0.232,P=0.817),治疗后观察组上述指标(1 552.34±870.38)IU/L、(405.36±103.28)IU/L水平低于对照组(1 985.20±923.14)IU/L、(456.20±112.73)IU/L(t=2.412,P=0.018;t=2.351,P=0.021);2组ALB和PA指标治疗前对比差异无统计学意义(t=0.029,P=0.974;t=0.385,P=0.701),治疗后观察组ALB(38.25±2.94)g/L高于对照组(35.84±3.63)g/L,PA(226.64±16.32)mg/L高于对照组(196.33±15.60)mg/L,组间对比差异有统计学意义(t=3.648,P<0.001;t=9.493,P<0.001)。结论奥曲肽应用于急性胰腺炎治疗中,能有效控制临床反应,改善生化指标,调节胃肠动力。

Objective To explore the clinical value of octreotide therapy in patients with acute pancreatitis. Methods A total of 100 patients with acute pancreatitis admitted to the hospital from March 2018 to October 2019 were enrolled.They were divided into observation group and control group by random number table method, and were selected into the two groups according to the principle of 50:50. The control group received conventional treatment, and the observation group received octreotide treatment. Record 2 groups of clinical symptoms, signs, blood and urine amylase recovery time, biochemical indicators before and after treatment, and blood Chemistry levels. Results In the observation group,vomiting was improved by 84.00%, abdominal distension improved by 88.00%, and anal exhaust and defecation 94.00%were higher than those in the control group(66.00%, 70.00%, 80.00%). There was statistically significant difference between the two groups(χ^2=4.320, P =0.038;χ^2=4.882, P =0.027;χ^2=4.332, P =0.037);the disappearance time of abdominal pain in the observation group(3.41 ±1.03)d, the recovery time of bowel sounds(3.35 ±0.68)d, body temperature(2.92±0.88)d, urine starch enzyme(3.70±1.56)d, blood amylase(5.28±1.14)d recovery time was shorter than the control group(4.66±1.31)d,(5.12±1.20)d,(4.34±1.12)d,(5.90±1.93)d,(8.44±1.86)d(t=5.304, P<0.001;t=9.074, P<0.001;t=7.049, P<0.001;t=6.268, P<0.001;t=10.242, P<0.001);urine amylase(2 086.56±1 050.23)IU/L, blood level of amylase before treatment in the observation group(512.12 ±175.41)IU/L compared with the control group(2 043.25±1 023.36)IU/L,(504.21±164.85)IU/L was not statistically significant(t=0.209, P=0.835, t=0.232, P=0.817), the observation group after treatment The indicators(1552.34±870.38)IU/L,(405.36±103.28)IU/L were lower than the control group(1 985.20±923.14)IU/L,(456.20±112.73)IU/L(t=2.412, P=0.018;t=2.351, P=0.021);the two groups of ALB and PA indicators before treatment had no statistical significance(t=0.029, P=0.974;t=0.385, P=0.701). After treatment, the ALB(38.25±2.94) g/L of the observation group was higher than that of the control group(35.84±3.63) g/L, PA(226.64±16.32) mg/L was higher than the control group(196.33±15.60) mg/L, and the comparison between groups was statistically significant(t=3.648, P<0.001;t=9.493, P<0.001). Conclusion The application of octreotide in the treatment of acute pancreatitis can effectively control clinical response, improve biochemical indicators, and regulate gastrointestinal motility.