胰岛素泵持续强化治疗妊娠期糖尿病的临床疗效

Clinical Effect of Continuous Intensive Treatment of Gestational Diabetes with Insulin pump

目的探究胰岛素泵持续强化治疗妊娠期糖尿病的临床疗效。方法将2018年1月—2019年12月该院接受妊娠期糖尿病治疗的75例患者作为试验对象。依据对象自主原则分组,成立参照(37例)及试验(38例)两组。参照组实施常规胰岛素注射治疗;试验组则采用胰岛素泵持续强化治疗。分析比对两组对象治疗前后血糖控制情况及不良事件发生情况。结果治疗后,试验组各项血糖指标[(5.22±0.34)mmol/L、(6.88±0.47)mmol/L、(6.11±0.29)%]相较于参照组[(6.31±0.47)mmol/L、(7.35±0.76)mmol/L、(6.55±0.47)%]呈现明显优越性(t=17.251、13.247、11.185);且该组胰岛素用量(32.45±1.76)U/d相较于参照组(43.12±2.91)U/d也呈现明显优越性(t=15.981);试验组各项不良事件发生率(5.26%、2.63%、21.05%、13.16%)相较于参照组(32.43%、27.03%、59.46%、51.35%)均呈现明显优越性(χ^2=4.618、4.517、6.288、6.367),各项对比结果数据均差异有统计学意义(P<0.05)。结论在治疗妊娠期糖尿病患者时应用胰岛素泵持续强化治疗疗效显著,能有效控制患者血糖水平,降低不良事件发生率,改善母婴结局。

Objective To explore the clinical effect of continuous intensive treatment of gestational diabetes with insulin pump. Methods From January 2018 to December 2019, 75 patients who received gestational diabetes treatment in the hospital were selected as the test subjects. Grouped according to the principle of subject autonomy, two groups of reference(37 cases) and trial(38 cases) were established. The reference group was given regular insulin injection therapy;the test group was given continuous intensive treatment with insulin pump. Analyze and compare the blood sugar control and adverse events of the two groups before and after treatment. Results After treatment, the blood glucose indexes of the test group [(5.22±0.34)mmol/L,(6.88±0.47)mmol/L,(6.11±0.29)%]were significantly superior to the reference group [(6.31±0.47)mmol/L,(7.35±0.76)mmol/L,(6.55±0.47)%](t=17.251,13.247,11.185);and the insulin dosage of this group(32.45 ±1.76) U/d compared with the reference group(43.12 ±2.91) U/d also showed obvious superiority(t=15.981);the incidence of adverse events in the experimental group(5.26%, 2.63%, 21.05%,13.16%)compared with the reference group(32.43%,27.03%,59.46%,51.35%) showed obvious superiority(χ^2=4.618,4.517,6.288,6.367), the comparative result data had statistically significant difference(P<0.05). Conclusion In the treatment of patients with gestational diabetes, continuous intensive treatment with insulin pump has a significant effect, which can effectively control the patient’s blood glucose level, reduce the incidence of adverse events, and improve maternal and infant outcomes.