宫颈癌及宫颈上皮内瘤变患者宫颈液基薄层细胞学检查及高危型人乳头瘤病毒检测的临床价值

Clinical value of detection of cervical thin-layer cytology test and high-risk human papilloma virus in patients with cervical cancer and cervical intraepithelial neoplasia

目的探讨宫颈癌及宫颈上皮内瘤变患者宫颈液基薄层细胞学检查(TCT)以及高危型人乳头瘤病毒(hrHPV)检测的临床价值。方法回顾性分析72例宫颈癌及宫颈上皮内瘤变患者的临床治疗情况。所有患者均采用TCT以及hrHPV检测,分析患者TCT、hrHPV检测的灵敏度、特异度以及与病理检查结果的符合率。结果72例患者TCT检测结果正常者42例,占58.3%(42/72),异常者为30例,占41.7%(30/72)。宫颈上皮内瘤变的TCT与病理学检查结果的符合率为44.2%(19/43),宫颈癌TCT与病理学检查结果的符合率为72.7%(8/11)。hrHPV检测显示,52例患者检测结果为阳性,占72.2%(52/72),20例为阴性,占27.8%(20/72),宫颈上皮内瘤变hrHPV检测与病理学检查结果的符合率为86.0%(37/43),宫颈癌TCT检测与病理学检查结果的符合率为90.9%(10/11)。72例患者进行TCT及hrHPV检测后结果显示,联合检测的灵敏度为94.4%,诊断符合率为90.3%,显著高于TCT或hrHPV单一检测。结论TCT、hrHPV联合检测有助于提高宫颈癌以及宫颈上皮内瘤变患者的检出率。

Objective To investigate the clinical value of cervical thin-layer cytology test( TCT) and high-risk human papilloma virus( hrHPV) detection in patients with cervical cancer and cervical intraepithelial neoplasia. Methods Clinical therapentic conditions of 72 cervical cancer and cervical intraepithelial neoplasia patients were retrospectively analyzed. All patients performed TCT and hrHPV. The sensitivities and specificities of TCT and hrHPV detection were analyzed,and their coincidence rates with pathological results were analyzed. Results TCT results of 72 patients showed that 42 cases presented normal results,accounting for 58. 3%( 42/72),and 30 cases were abnormal,accounting for 41. 7%( 30/72). The rate of TCT detection that was in with pathological results of cervical intraepithelial neoplasia was 44. 2%( 19/43),the rate of TCT detection that was in with pathological results of cervical cancer was 72. 7%( 8/11). The hrHPV test results showed that 52 patients were positive,accounting for 72. 2%( 52/72),and 20 patients were negative,accounting for 27. 8%( 20/72).The rate of hrHPV detection accordance with pathological results was 86. 0%( 37/43) in diagnosis of cervical intraepithelial neoplasia and was 90. 9%( 10/11) by TCT in diagnosis of cervical cancer.The sensitivity and coincidence rate of TCT and hrHPV combined detection were 94. 4% and 90. 3%respectively,which were significantly higher than TCT or hrHPV detection alone. Conclusion TCT and hrHPV combined detection can improve the detection rate of patients with cervical cancer and cervical intraepithelial neoplasia.