难治性精神分裂症患者白细胞介素水平分析

Analysis of interleukin levels in patients with treatment-resistant schizophrenia

目的探讨难治性精神分裂症(TRS)血清白细胞介素-4(IL-4)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平。方法纳入TRS患者112例,非TRS的慢性期精神分裂症患者117例,对照组113例,均为男性。采用阳性与阴性症状量表(PANSS)评估患者的精神症状。采用酶联免疫吸附法(ELISA)方法检测所有受试者的血清IL-4、IL-6、IL-8水平。结果TRS组和精神分裂症组的IL-6、IL-8均高于对照组,差异有统计学意义(P<0.05),但TRS组和精神分裂症组IL-8比较,差异无统计学意义(P>0.05);3组IL-4水平比较,差异无统计学意义(P>0.05)。TRS组与对照组,受试者工作特征曲线(ROC)的曲线下面积(AUC)为0.823。结论TRS患者存在明显的免疫异常,而IL-6可能是TRS重要的生物学指标。

Objective To investigate the levels of serum interleukin-4( IL-4),interleukin-6( IL-6) and interleukin-8( IL-8) in patients with treatment-resistant schizophrenia( TRS). Methods A total of 112 male patients with TRS,117 male patients with non-TRS chronic schizophrenia and 113 healthy controls were enrolled. The mental symptoms of the patients were evaluated by Positive and Negative Syndrome Scale( PANSS). Enzyme-linked immunosorbent assay( ELISA) method was used to detect serum IL-4,IL-6 and IL-8 levels. Results The levels of IL-6 and IL-8 in the TRS group and schizophrenia group were significantly higher than those in the control group( P < 0. 05),but there was no significant difference in IL-8 between the TRS group and the schizophrenia group( P >0. 05). There was no significant difference in IL-4 level among three groups( P > 0. 05). The area under curve( AUC) of receiver operating characteristic curve( ROC) was 0. 823 for TRS group and control group. Conclusion There are obvious immune abnormalities in TRS patients,and IL-6 may be important biological indicators of TRS.