脂肪来源干细胞抑制病理性瘢痕形成的临床研究进展

Clinical Research Progress of Adipose-derived Stem Cells Inhibiting The Formation of Pathological Scars

皮肤病理性瘢痕是皮肤结缔组织的增生性疾病,病理改变主要以成纤维细胞大量增殖和细胞外基质沉积为主,其发病机制错综复杂,至今尚未完全阐明。近年来,随着对干细胞研究的不断深入,脂肪来源干细胞(Adipose-derived stem cells,ADSCs)逐渐显露出防治病理性瘢痕的潜力。现对病理性瘢痕病理生理的研究进展进行简单总结,并对ADSCs参与病理性瘢痕抗纤维化的可能机制进行总结。ADSCs可能通过TGF-β1(Transforming growth factor-β1)及有关信号通路的调节,免疫调节,减轻炎症反应,抑制成纤维细胞增殖及促进细胞外基质重塑来防治病理性瘢痕的纤维化。

Skin pathological scar is a proliferative disease of skin connective tissue.The pathological changes are mainly fibroblast proliferation and extracellular matrix deposition.The pathogenesis of skin pathological scar is complex and has not yet been fully elucidated.In recent years,with the deepening of stem cell research,adipose-derived stem cells(ADSCs)gradually show the potential of preventing and treating pathological scars.This article summarizes the research progress of pathophysiology of pathological scar,and summarizes the possible mechanism of ADSCs participating in anti-fibrosis of pathological scar.ADSCs may prevent and treat fibrosis of pathological scars by regulating TGF-β1(transforming growth factor-β1)and related signaling pathways,immune regulation,alleviating inflammation,inhibiting fibroblast proliferation and promoting extracellular matrix remodeling.