双歧杆菌四联活菌对乙型肝炎相关慢加急性肝衰竭患者肠道菌群、炎症免疫和肝功能的影响

Study on the effect of tanreqing injection on acute stroke complicated with pulmonary infection and inflammatory index

目的:探讨双歧杆菌四联活菌对乙型肝炎相关慢加急性肝衰竭(HBV-ACLF)的治疗效果。方法:将78例HBV-ACLF患者分成观察组和对照组,对照组给予常规治疗和生活干预,观察组在对照组基础上口服双歧杆菌四联活菌片,观察两组患者肠道菌群、炎症免疫和肝功能指标的变化。结果:治疗4周后,观察组的双歧杆菌、乳酸杆菌、变形杆菌和酵母样菌属等肠道菌落数、肿瘤坏死因子-α和白细胞介素-6等炎症指标、CD4^+和CD4^+/CD8^+值等免疫指标、以及血清白蛋白、总胆红素、胆汁酸、谷丙转氨酶和碱性磷酸酶肝功能水平均较对照组显著改善(P<0.05)。结论:HBV-ACLF患者口服双歧杆菌四联活菌片辅助治疗,能显著改善肠道微生态环境,控制机体炎症水平,提高免疫能力,促进肝功能恢复,改善疾病预后。

Objective:Objective:Objective to investigate the effect of bifidobacterium quadruplex on hepatitis b related chronic liver failure(hbv-aclf).Methods:The 78 patients with hbv-aclf were divided into the observation group and the control group.The control group was given routine treatment and life intervention,and the observation group was given oral adjuvant treatment with bifidobacterium quadruplus-viable tablets to observe the changes of intestinal flora,inflammatory immunity and liver function indexes.Results:After 4 weeks of treatment,the number of intestinal colonies such as bifidobacterium,lactobacillus,proteus and yeast-like bacteria in the observation group,inflammatory indicators such as tnf-beta and il-6,immune indicators such as CD4^+ and CD4^+/CD8^+ values,and liver function levels of ALB,TBiL,TBA,ALT and ALP were significantly improved compared with the control group(P>0.05).Conclusion:Oral adjuvant therapy with bifidobacterium quadruplets for patients with hbv-aclf can significantly improve the intestinal microecological environment,control the level of inflammation,improve the immune capacity,promote the recovery of liver function and improve the prognosis of the disease.