黄精丸治疗轻中度阿尔茨海默病临床研究

Clinical Study on Huangjing Pills in the Treatment of Mild and Moderate Alzheimer Disease

目的观察黄精丸治疗轻中度阿尔茨海默病(AD)临床疗效。方法采用随机数字表法将97例轻中度AD患者分为对照组49例和研究组48例。对照组予盐酸多奈哌齐片,5 mg/d,口服;研究组予黄精丸,1丸/次,2次/d,口服。2组均1个月为1个疗程,疗程间停药1周,共治疗3个疗程。观察2组临床疗效,比较2组治疗前后简易精神状态检查量表(MMSE)评分、改良长谷川痴呆量表(HDS-R)评分、日常生活活动能力量表(ADL)评分,检测2组治疗前后血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、白细胞介素-1β(IL-1β)水平,监测2组不良反应。结果研究组总有效率为91.7%(44/48),对照组为81.6%(40/49),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后MMSE、HDS-R、ADL评分明显升高(P<0.05);2组治疗后比较,研究组MMSE、HDS-R、ADL评分明显高于对照组(P<0.05)。与本组治疗前比较,研究组治疗后血清SOD、GSH-Px活性升高,血清MDA、IL-1β水平降低(P<0.05);2组治疗后比较,研究组血清SOD、GSH-Px活性高于对照组,MDA、IL-1β水平低于对照组(P<0.05)。对照组不良反应发生率为36.7%(18/49),研究组未见不良反应。结论黄精丸治疗轻中度AD临床疗效较好,可改善患者痴呆症状,提高其认知功能及生活能力,降低机体氧化应激水平。

Objective To observe the clinical efficacy of Huangjing Pills in the treatment of patients with mild and moderate Alzheimer disease(AD).Methods Totally 97 patients with mild and moderate AD were divided into the control group and the study group according to random number table method,with 49 patients in the control group,and 48 patients in the study group.The control group was given routine treatment with donepezil hydrochloride tablets,5 mg/d,orally.The study group was given Huangjing Pills,one pill each time,twice a day,orally.One month was a course of treatment,and then the medicine was stopped for 1 week.A total of 3 courses were treated.The clinical efficacy of both groups was observed.The scores of the Mini Mental State Examination Scale(MMSE),the modified Hasegawa Dementia Scale(HDS-R),and the Activity of Daily Living Scale(ADL)scores were compared between the two groups before and after treatment.Superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA),and interleukin-1β(IL-1β)levels were detected before and after treatment in the two groups.Adverse reactions in 2 groups were monitored.Results The total effective rate was 91.7%(44/48)in the study group and 81.6%(40/49)in the control group,with statistical significance(P<0.05).Compared with before treatment,the scores of MMSE,HDS-R and ADL in the two groups were significantly increased(P<0.05);after treatment,the scores of MMSE,HDS-R and ADL in the study group were significantly higher than those in the control group(P<0.05).Compared with before treatment,the serum SOD and GSH-Px activities in the study group were increased after treatment,and the serum MDA and IL-1βlevels were decreased(P<0.05).After treatment,the SOD and GSH-Px activities in the study group were higher than those of the control group,and the levels of MDA and IL-1βwere lower than those of the control group(P<0.05).The incidence of adverse reactions in the control group was 36.7%(18/49),and there were no adverse reactions in the study group.Conclusion Huangjing Pills has good clinical efficacy on the treatment of AD.It can improve the symptoms of AD,improve the cognitive function and living ability,and reduce the level of oxidative stress of the body.