生物钟基因Bmal1与骨代谢相关性的研究进展

Research progress on the relationship between clock gene Bmal1 and bone metabolism

骨代谢相关疾病在全球范围内成为日益增加的健康负担,仍需要进一步基础研究以更好地了解这些疾病的发病机制并改善和扩展现有的预防和治疗方法。昼夜节律生物钟可调控多种生物的生理和病理。在骨骼中,昼夜节律有助于协调骨骼的形成和吸收。Bmal1是核心生物钟基因,在昼夜节律的调节中起着重要作用,参与骨骼形成的节律振荡和细胞外基质表达。软骨细胞、成骨细胞及破骨细胞对骨的完整性和功能性起重要作用。Bmal1的异常表达会影响骨代谢,反之骨代谢也会影响Bmal1的表达。

Bone metabolism-related diseases have become an increasing health burden worldwide and further basic research is still needed for a better understanding of the pathogenesis of these diseases and improving and expanding existing prevention and treatment methods.Circadian circadian clock can regulate the physiology and pathology of many organisms.In bones,circadian rhythms help coordinate bone formation and absorption.Bmal1 is the core biological clock gene,which plays an important role in the regulation of circadian rhythm,participates in the rhythm oscillation of bone formation and the expression of extracellular matrix.Chondrocytes,osteoblasts and osteoclasts play an important role in the integrity and function of bone.The abnormal expression of Bmal1 would affect bone metabolism,and vice versa,bone metabolism would also affect the expression of Bmal1.