不同生物制剂对小儿急性腹泻的止泻效果比较及其对胃肠道菌群分布的影响

Impact of Different Biological Agents to Children with Acute Diarrhea and the Distribution of Gastrointestinal Flora

目的:探讨不同生物制剂对小儿急性腹泻的止泻效果及其对胃肠道菌群分布的影响分析。方法:选择2014年10月~2017年10月本院小儿科200例急性腹泻的患儿为研究对象,采用随机数字分组法随机分为2组,每组100例。两组均采用常规的抗感染、补液、纠正水电解质及酸碱平衡紊乱治疗。观察组采用双歧杆菌三联活菌胶囊治疗,对照组采用整肠生治疗,并根据患儿不同的年龄选择不同适宜剂量。对比观察两组患儿的临床疗效及其对胃肠道菌群分布的影响。结果:经治疗后,观察组的总有效率(90.90%)明显高于对照组(81.63%),差异具有统计学意义(P<0.05);观察组的痊愈率为63.64%(63/98),对照组为44.90%(44/98),两组痊愈率比较差异具有统计学意义(P<0.01);两组痊愈患者的痊愈时间比较,观察组较对照组短,差异均具有统计学意义(P<0.05);粪便中菌种变化方面,两组的需氧菌比例均有不同程度下降(P均<0.05),而观察组下降更多(P<0.05),差异具有统计学意义;与治疗前比较,观察组厌氧菌比例升高,差异具有统计学意义(P<0.01),对照组升高不明显,差异无统计学意义(P>0.05)。此外两组治疗后厌氧/需氧比例的比值比较,观察组高于对照组,差异具有统计学意义(P<0.05)。两组均无明显的不良反应发生事件发生。结论:采用双歧杆菌三联活菌胶囊治疗小儿急性腹泻较使用整肠生临床疗效好、安全性较高,能有效调整胃肠道菌群平衡、恢复胃肠道正常功能,值得临床推广应用。

Objective:To investigate the effect of different biological agents in children with acute diarrhea,and its influence on the gastrointestinal flora distribution.Methods:200 cases of acute diarrhea admitted in the hospital pediatric department from October 2014 to 2017 October were included in the study.According to the random number table methods,patients were randomly divided into two groups,each group 100 cases.Both groups were provided with conventional antibiotics and rehydration to correct water and electrolyte and acid-base balance disorders.Bifidobacteria treatment was provided in the observation group,and the control group was treated with Zhengchangsheng treatment.Appropriate dose was provided according to the age of children.Clinical efficacy and the influence on the distribution of gastrointestinal flora were compare between the two groups.Results:After treatment,the total efficiency in the observation group(90.90%)was significantly higher than that in the control group(81.63%),with statistical significance(P<0.05);the cured rate in the observation group was 63.64%(63/98),control group with 44.90%(44/98)in the control group,with significant difference(P<0.01);and comparing the healing time in the two groups,shorter result was obtained in the observation group than in the control group,with significant difference(P<0.05).Considering the changes in terms of fecal bacteria,aerobic ratio levels decreased in both groups with different degree(P<0.05),with more reduction found in the observation group(P<0.05);Comparing with before treatment,the proportion of anaerobic bacteria in the observation group was significantly increased(P<0.01),while the increase in the control group was not obvious(P>0.05).After treatment,the ratio of anaerobic/aerobic proportion was significantly higher in the observation group than in the control group(P<0.05).There were no significant adverse events occurred in both groups.Conclusion:The control group with the Zhengchangsheng treatment,the use of bifidobacteria in the treatment of children with acute diarrhea shows better clinical efficacy,higher safety,and can effectively adjust the gastrointestinal flora balance and restore the normal function of the gastrointestinal tract,which is worthy of clinical application.