一种营养配方粉对肿瘤患者营养治疗效果的临床观察

Clinical observation on the effect of functional food on nutritional therapy of cancer patients

目的初步探讨一种营养配方粉对恶性肿瘤患者的营养改善作用。方法选取10家医院于2019年4月至10月所收治的恶性实体瘤患者248例,分为对照组(154例)及营养粉组(94例),营养粉组肿瘤患者每天早晚各服用30g营养粉,按不同服用时长,分为四个组:服用15~30d为A组(9例);服用31~60d为B组(25例);服用61~90d为C组(44例);服用90d以上为D组(16例);另外154例患者作为未服用营养粉对照组。纳入人群均接受放疗或化疗。试验过程中收集患者相关临床指标,评价营养粉的安全性及患者依从性,记录并分析各组治疗前后的体力、总体生活质量评分、食欲评分、白细胞计数、体重及血清白蛋白水平等营养状态指标。结果与对照组肿瘤患者相比,服用营养粉的患者在白细胞、体重、白蛋白等营养指标,以及体力、生活质量、食欲等一般情况均优于对照组;服用营养粉1个月后,大部分肿瘤患者白细胞及白蛋白能够维持在正常水平且明显高于对照组;肿瘤患者的平均体重维持在放化疗前水平,但与对照组差异无统计学意义;营养粉对胃肠道肿瘤患者的体力及总体生活质量的改善作用更为显著。结论营养粉可显著改善恶性肿瘤患者的营养状况,安全性好,可作为辅助抗肿瘤治疗方法。

Objective To investigate a nutritional improvement effect of functional food on patients with malignant tumors.Methods A total of 248 patients with tumor admitted to 10 hospitals from April to October 2019 were selected and were divided into the control group(154 patients)and the functional group(94 patients).They all received radiotherapy or chemotherapy.Tumor patients in the functional group taking 30g of functional nutrition powder in the morning and evening were divided into four groups according to different durations:9 in group A(15-30d),25 in group B(31-60d),44 in group C(61-90d),16 in Group D(≥90d).The other 154 patients received radiotherapy or chemotherapy as the control group not taking functional food.During the experiment,relevant clinical indicators of patients were collected to evaluate the safety and patient compliance of functional food,and the physical strength,overall quality of life score,appetite score,white blood cell count,body weight,serum albumin level and other nutritional status indicators of each group before and after treatment were recorded and analyzed.Results Compared with the control group,the patients who took functional food had better nutrition indicators such as white blood cell weight and albumin,as well as physical life quality and appetite.After taking functional food for 1month,most of the tumor patients could maintain the normal levels of white blood cells and albumin.The average weight of the nutrition group was maintained at the pre-chemoradiotherapy level and higher than that of the control group(no statistical significance).The effect of the nutrition powder on the physical strength and overall quality of life of patients with gastrointestinal tumors was more significant.Conclusion The functional food can significantly improve the nutritional status of malignant tumor patients,good safety,can be used as an adjuvant anti-tumor therapy.