SAA、CRP和LYMPH#在新型冠状病毒肺炎临床分型和疗效评估中的价值

Roles of SAA,CRP and LYMPH#in clinical classification and efficiency evaluation of corona virus disease 2019

目的探讨血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)和淋巴细胞绝对数(LYMPH#)在新型冠状病毒肺炎(COVID-19)临床分型和疗效评估中的价值。方法选取COVID-19患者45例(轻症31例、重症14例,均好转出院),以50例最终排除严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染的疑似患者作为疾病对照组,以60名体检健康者作为正常对照组。检测所有对象的SAA、CRP和LYMPH#。结果COVID-19重症组SAA、CRP和LYMPH#与COVID-19轻症组、疾病对照组、正常对照组比较,差异均有统计学意义(P<0.05)。COVID-19轻症组CRP低于疾病对照组(P<0.05),SAA、LYMPH#2个组之间差异均无统计学意义(P>0.05)。COVID-19轻症组SAA高于正常对照组(P<0.05),LYMPH#低于正常对照组(P<0.05),CRP 2个组之间差异无统计学意义(P>0.05)。与入院时比较,COVID-19组出院时SAA、CRP明显降低(P<0.05),LYMPH#明显升高(P<0.05)。结论SAA、CRP和LYMPH#在COVID-19的临床分型及疗效评估中有一定的价值。

Objective To study the roles of serum amyloid A(SAA),C-reactive protein(CRP)and the absolute value of lymphocyte(LYMPH#)in clinical classification and efficiency evaluation of corona virus disease 2019(COVID-19).Methods Totally,45 patients with COVID-19,including 31 cases of light type and 14 cases of severe type,which were all improved and discharged,were enrolled,and 50 suspected patients without severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection were enrolled as disease control group.A total of 60 healthy subjects were enrolled as healthy control group.SAA,CRP and LYMPH#were determined.Results In severe type group,SAA,CRP and LYMPH#in light type group,disease control group and healthy control group had statistical significance(P<0.05).CRP in light type group was lower than that in disease control group(P<0.05),and there was no statistical significance for SAA and LYMPH#between the 2 groups(P>0.05).SAA in light type group was higher than that in healthy control group(P<0.05),and LYMPH#was lower(P<0.05).There was no statistical significance for CRP between the 2 groups(P>0.05).Compared with the time of admission,SAA and CRP in COVID-19 group were decreased(P<0.05),and LYMPH#was increased(P<0.05).Conclusions SAA,CRP and LYMPH#play roles in clinical classification and efficiency evaluation of COVID-19.