血清胆红素、肌酸激酶同工酶MB质量与新生儿日龄的相关性

Correlation of serum bilirubin and CK-MB mass with age in newborns

目的探讨血清胆红素[总胆红素(TB)、直接胆红素(DBil)]、肌酸激酶同工酶MB质量(CKMB mass)水平与新生儿日龄的关系。方法选取106名日龄为0~28 d的新生儿,根据出生天数分为3组:≤5 d组(48例)、>5~≤10 d组(32例)、>10~≤28 d组(26例)。采用Spearman相关分析评估各项指标与日龄的相关性。结果>5~≤10 d组血清TB水平明显高于≤5 d组和>10~≤28 d组(P<0.001),>10~≤28 d组血清DBil水平明显高于≤5 d组和>5~≤10 d组(P<0.001),≤5 d组、>5~≤10 d组、>10~≤28 d组血清CK-MB mass水平依次降低(P<0.05)。TB与日龄无相关性(r=0.038,P>0.05),DBil与日龄呈正相关(r=0.469,P<0.05),CK-MB mass与日龄呈负相关(r=-0.559,P<0.05)。结论新生儿血清DBil、CK-MB mass水平与日龄有一定的关系。

Objective To investigate the relationship between total bilirubin(TB),direct bilirubin(DBil)and creatine kinase isoenzyme MB mass(CK-MB mass)with age in newborns.Methods A total of 106 newborns aged 0-28 d were classified into 3 groups according to birth days,which included≤5 d group(48 cases),>5-≤10 d group(32 cases)and>10-≤28 d group(26 cases).Spearman correlation analysis was used to evaluate the correlation between each index and age.Results Serum TB level in>5-≤10 d group was higher than those in≤5 d and>10-≤28 d groups(P<0.001),and DBil level in>10-≤28 d group was higher than those in≤5 d and>5-≤10 d groups(P<0.001),while serum CK-MB mass in≤5 d,>5-≤10 d and>10-≤28 d groups was decreased in turn(P<0.05).There was no correlation between TB and age(r=0.038,P>0.05),DBil was correlated positively with age(r=0.469,P<0.05),and there was a negative correlation between CK-MB mass and age(r=-0.559,P<0.05).Conclusions DBil and CK-MB mass in newborns have a certain relationship with age.