代谢组学在纳米毒理学研究中的应用

Application of metabolomics in nanotoxicity

纳米粒子作为一种具有优良性能的新兴材料,在化工、纺织、生物医药等多个领域广泛应用,引起了社会对其潜在毒性的高度关注,由于传统毒理学技术的限制,迫切需要高通量方法来系统性评估纳米粒径尺度下粒子的潜在毒性。代谢组学是现代分析技术、生物化学及生物信息学等多学科交叉组合发展起来的新兴组学技术,通过分析细胞、组织等生物样品内代谢物种类及数量的变化,筛选早期毒性潜在标志物及相关代谢通路,是纳米粒子毒理学研究的重要高通量技术手段。本文拟从代谢组学在纳米毒理学研究中的应用进展和挑战等方面进行综述性回顾。

As an emerging material with excellent property,nanoparticle has been widely used in multiple fields such as chemical industry,textile,biomedicine,etc.,which has caused widespread concern about its potential toxicity in society.Due to the limitations of traditional toxicology technology,the high-throughput methods were urgently needed to assess the potential toxicity of particles at nanoparticle size systematically.Metabolomics has been recognized as an emerging omics technology developed by multidisciplinary combination of modern analytical techniques,biochemistry and bioinformatics,which has been widely used to screened early toxicity potential markers and metabolic pathway by analyzing changes in the types and quantities of metabolites in biological samples such as cells and tissues.This article reviewed the progress and challenges of metabolomics in nanotoxicology research.