血清IL-6联合PCT检验对儿童脓毒症病情的评估

Value of serum interleukin-6 and procalcitonin combined detection in evaluation of disease condition of infection-associated sepsis in children

目的探讨血清白介素-6(IL-6)联合降钙素原(PCT)检验对感染相关儿童脓毒症患儿病情评估的价值。方法选取2018年12月至2019年12月在内蒙古医科大学附属医院儿科诊治疑似感染相关儿童脓毒症100例患儿资料,经快速序贯器官衰竭评估(qSOFA)评分≥2分,将其设为研究组;选择同期健康儿童60例资料设为对照组。两组均采用血清IL-6联合PCT检验,分析其与儿童脓毒症病情及预后的相关性。结果研究组的血清IL-6和PCT水平均高于对照组,差异均有统计意义(t值分别为6.9129、8.0120,均P<0.01)。研究组的血清IL-6和PCT敏感度及特异度均较高,但差异均无统计学意义(χ^2值分别为1.8706、1.9762,均P<0.05)。研究组中的脓毒症组血清IL-6和PCT水平均高于非脓毒症组,差异均有统计学意义(t值分别为6.3914、7.0795,均P<0.01);脓毒症组中的预后良好组血清IL-6和PCT水平均低于预后不良组,差异均有统计学意义(t值分别为3.6743、8.4279,均P<0.01)。结论在疑似感染相关儿童脓毒症患儿中应用血清IL-6联合PCT检验,可诊断是否感染脓毒症,其敏感度、特异度均较高,为临床治疗及预后效果提供依据,有一定的临床应用价值。

Objective To analyze value of serum interleukin-6(IL-6)and procalcitonin(PCT)combined detection in evaluation of disease condition of infection-associated sepsis in children.Methods The clinical data of 100 children who were diagnosed as suspected infection-associated sepsis and treated in our hospital from December 2018 to December 2019 were collected.The children with score in quick Sequential Organ Failure Assessment(qSOFA)≥2 points were enrolled in the study group,and another 60 healthy children during the same period were selected as the controls.Serum levels of IL-6 and PCT of all children in the two groups were detected.The correlations of serum levels of IL-6 and PC with disease condition and prognosis of sepsis in children were analyzed.Results The serum levels of IL-6 and PCT of the children in the study group were both higher than those of the children in the control group,and the differences were statistically significant(t=6.9129,t=8.0120,both P<0.01).The sensitivity and specificity of serum IL-6 and PCT in the study group were both higher,but there were no differences between IL-6 and PCT(χ^2=1.8706 and 1.9762 respectively,both P>0.05).The serum IL-6 and PCT levels of the children in sepsis subgroup in the study group were both higher than those of the children in non-sepsis subgroup in the study group and there were significant differences between the two subgroups(t=6.3914,t=7.0795,both P<0.01).In sepsis subgroup,the serum levels of IL-6 and PCT in good prognosis subgroup were both lower than those in the poor prognosis subgroup,and there were significant differences between the two subgroups(t=3.6743,t=8.4279,both P<0.01).Conclusion For those children with suspected infection-associated sepsis,the combined detection of serum IL-6 and PCT levels can determine the diagnosis of infection-associated sepsis in children,and it can provide some basis for clinical treatment and judgement of prognosis of the disease due to their higher sensitivity and specificity,therefore,the combined detection is of some application values in clinic.