不同运动频次对高尿酸血症患者痛风发作率、血清肌酐水平、尿酸水平及尿pH值的影响

Effects of different exercise frequency on the incidence of gout,the serum levels of creatinine and uric acid as well as urinary pH value in patients with hyperuricemia

目的探讨不同运动频次对高尿酸血症(HUA)患者痛风发作率、血清肌酐(Scr)水平、尿酸(UA)水平及尿pH值的影响。方法选择2017年4月至2019年3月收治的258例HUA患者,按不同运动频次分成A组(不运动)55例、B组(运动1~4次/月)64例、C组(1 h/次且4~5次/周)64例、D组(1 h/次且30次/月,极重度升高)62例。比较不同运动频次对患者痛风发作率,Scr、UA水平及尿pH值的影响。结果A组和D组的痛风发作率分别为73.85%和62.90%,显著高于痛风不发作率,B组和C组痛风发作率分别为35.94%和32.84%,显著低于痛风不发作率,差异有统计学意义(P<0.05),同时B组和C组的痛风不发作率显著高于A组和D组,痛风发作率显著低于A组和D组,差异有统计学意义(P<0.05)。A组Scr水平均低于B、C组,B组高于D组,C组高于D组,差异有统计学意义(P<005),而4组中男性UA水平均高于女性,且A组UA水平均高于B、C组,B组低于D组,C组低于D组,差异有统计学意义(P<0.05),而A、D组、B、C(男、女)组的Scr、UA值相比均无显著差异(P>0.05)。3)A、D组中男性的pH值均低于女性,A组pH值低于B、C组,B组高于D组,C组高于D组,差异显著(P<0.05),而A、D组、B、C(男、女)组及pH值相比均无显著差异(P>0.05)。结论在HUA患者的临床诊治过程中,科学、合理的予以每月1~4次,每小时1次及每周4~5次的运动频次干预,能有效的降低痛风发作率,且在这两个运动频次内患者的Scr、UA及尿pH值改善也更显著,有较好的临床应用价值。

Objective To investigate the effects of different exercise frequency on the incidence of gout,the serum levels of creatinine(CRE),uric acid(UA)as well as urinary pH value in patients with hyperuricemia(HUA).Methods A total of 258 patients with HUA who were admitted and treated in our hospital from April 2017 to March 2019 were enrolled in thestudy,who were divided into group A(no exercise,slight increase of blood uric acid,n=55),group B(exercise(1~4 times a month,moderate increase of blood uric acid,n=64),group C(1h once,4~5 times a week,severe increase of blood uric acid,n=64),group D(1h once,30 times a month,extremely severe increase of blood uric acid,n=62).The effects of different exercise frequencies on the gout attack rate,and the levels of SCR and UA as well as urinary pH value were observed and compare among the four groups.Results The incidence rate of gout attack in group A and group D was 73.85%and 62.90%,respectively,which was significantly higher than that in patients without gout attack,which in group B and group C was 35.94%and 32.84%,respectively,which was significantly lower than that in patients without gout attack(P<0.05).Moreover the incidence rates without gout attack in group B and group C were significantly higher than those in group A and group D,however,the incidence rates of gout attack were significantly lower than those in group A and group D(P<0.05).In addition the SCR levels in group A were significantly lower than those in group B and C,which in group B were significantly higher than those in group D,which in group C were significantly higher than those in group D(P<0.05).Moreover the UA levels in male patients were significantly higher than those in female patients,which in group A were significantly higher than those in group B and C,which in group B and in group C were significantly lower than those in group D(P<0.05),but there were no significant differences in the levels of SCR and UA among the four groups(P>0.05).And the pH levels in male patients in group A and group D were significantly lower than those in female patients,which in group A were significantly lower than those in group B and group C,which in in group B and group C were significantly higher than those in group D(P<0.05).Conclusion In the process of clinical diagnosis and treatment of patients with HUA,scientific and reasonable intervention of exercise frequency of 1~4 times a month,1 time an hour and 4~5 times a week can effectively reduce the incidence of gout attack,and improve the levels of SCR,UA and urinary pH,which has better clinical application value.