住院慢性复退军人精神分裂症临床症状的相关因素分析

Analysis of the related factors with the clinical symptoms of veterans patients with chronic schizophrenic in hospitalization

目的探讨影响住院慢性复退军人精神分裂症临床症状的相关因素。方法采用阳性与阴性症状量表(PANSS)对患者的精神病理状况进行测评,采用中文版可重复神经心理状态测验(RBANS)评估患者的认知功能,采用t检验、ANOVA分析、Person相关分析及回归分析等系列方法对数据资料进行分析。结果家人对患者关心者的阴性分量表分显著低于不关心者(P=0.023)。Person相关分析:阳性量表分与语言分呈显著正相关(P=0.027),阴性量表分与RBANS各分量表分及总分均呈显著或极显著呈负相关(P=0.012、0.004、<0.001、0.002、0.001、<0.001),正性因子分与语言分呈显著正相关(P=0.044),负性因子分与RBANS各分量表分及总分均呈极显著负相关(P=0.010、0.003、<0.001、<0.001、<0.001、<0.001),抑郁/焦虑因子分与即刻记忆、注意及RBANS总分呈显著正相关(P=0.044、0.015、0.022);回归分析:以阴性量表分及负性因子分为因变量的方程有统计学意义(P<0.001);语言、注意对阴性量表分的影响有统计学意义(P=0.003、0.050),延时记忆的影响接近统计学意义(P=0.072);语言对负性因子分的影响也有统计学意义(P=0.004)。结论住院慢性复退军人精神分裂症的各个症状群并不是一个独立的单元,其间有着关联,尤其阴性症状与认知损害之间关系密切。

Objective To investigate the related factors influencing the clinical symptoms of veterans patients with chronic schizophrenic in hospitalization.Methods The mental pathological status of veterans patients with chronic schizophrenic in hospitalization was assessed by means of positive and negative symptom scale(PANSS),and the cognitive function of patients was evaluated by means of Chinese version of the repeatable neuropsychological state test(RBANS).The data were statistically analyzed by t test,ANOVA analysis,Person related analysis and regression analysis.Results The scores of negative subscale of family members to patients were significantly lower than those of family members who did not care about them(P<0.05).Person correlation analysis showed that the positive scale scores were positively correlated with language scores(P<0.05),and the negative scale scores were negatively correlated with the total scores of RBANS(P<0.05).Moreover the positive factor scores were positively correlated with language scores(P<0.05),and the negative factor scores were negatively correlated with the total scores of RBANS(P<0.05).In addition the depression/anxiety factor scores were positively correlated with the scores of immediate memory,attention and the total score of RBANS(P<0.05).The regression analysis showed that the equation with negative scale scores and negative factor scores as dependent variables was statistically significant(P<0.001),and the effects of language and attention on the negative scale scores were statistically significant(P<0.05).Conclusion The symptom group in veterans patients with chronic schizophrenic in hospitalization is not an independent unit,there is correlation among them,especially,there is a close relationship between negative symptoms and cognitive impairment of patients.