血清CTRP1、尿酸水平在冠心病临床诊断中的应用价值

The value of serum CTRP1 and uric acid levels in clinical diagnosis of coronary heart disease

目的探讨血清C1q肿瘤坏死因子相关蛋白(CTRP1)、尿酸(SUA)水平在冠心病临床诊断中的应用价值。方法选取2019年1月至2019年12月间收治的冠心病患者140例作为研究对象(观察组),根据疾病类型分为心肌梗死组(AMI组,n=46)、不稳定心绞痛组(UA组,n=75)和慢性稳定性心绞痛组(SAP组,n=19),并选取同期体检健康者50例作为对照组。比较各组一般资料[性别、年龄、体质量(BMI)、收缩压、血肌酐(SCr)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)]及血清CTRP1、SUA水平,比较不同类型冠心病患者血清CTRP1、SUA水平,分析血清CTRP1、SUA诊断冠心病的效能,分析冠心病患者病情严重程度与血清CTRP1、SUA的关系。结果两组SCr、TC比较差异无统计学意义(P>0.05),观察组BMI、收缩压、TG、SUA均高于对照组,差异具有统计学意义(P<0.05),观察组LDL-C、CTRP1均低于对照组,差异具有统计学意义(P<0.05);不同组中CTRP1水平比较结果:对照组>SAP组>UA组>AMI组,差异具有统计学意义(P<0.05);SUA水平比较结果:对照组<SAP组<UA组<AMI组,差异具有统计学意义(P<0.05);ROC曲线显示CTRPI、SUA均是诊断冠心病的有效指标(P<0.05),CTRPI、SUA联合诊断曲线下面积(AUC)最大;不同冠心病病变支数者CTRP1水平比较结果:三支<双支<单支<对照组,差异具有统计学意义(P<0.05);SUA水平比较结果:三支>双支>单支>对照组,差异具有统计学意义(P<0.05)。结论血清CTRP1、SUA与冠心病患者及其血管病变支数相关,CTRP1联合SUA诊断冠心病效能较高。

Objective To explore the value of serum C1q tumor necrosis factor-related protein(CTRP1)and uric acid(SUA)levels in the clinical diagnosis of coronary heart disease.Methods 140 patients with coronary heart disease admitted between January 2019 and December 2019 were selected as the research subjects(observation group),and the patients in observation group were divided into the myocardial infarction group(AMI group,n=46),the unstable angina group(UA group,n=75)and the chronic stable angina pectoris group(SAP group,n=19)according to the types of disease.Another 50 healthy people who underwent physical examination during the same period were selected as the control group.The general data[gender,age,body mass index(BMI),systolic blood pressure,blood creatinine(SCr),total cholesterol(TC),triglycerides(TG),low density lipoprotein-cholesterol(LDL-C)]and levels of serum CTRP1 and SUA were compared between the two groups.Levels of serum CTRP1 and SUA were compared among patients with different types of coronary heart disease.The efficacy of serum CTRP1 and SUA was analyzed in the diagnosis of coronary heart disease.The relationship between the disease severity of patients with coronary heart disease and serum CTRP1 and SUA levels was analyzed.Results There were no significant differences in SCr and TC between the two groups(P>0.05),and the BMI,systolic blood pressure,TG and SUA in the observation group were higher than those in the control group(P<0.05),while the LDL-C and CTRP1 in the observation group were lower than those in the control group(P<0.05).Comparison of CTRP1 level in the different groups showed that the control group>the SAP group>the UA group>the AMI group(P<0.05).Comparison of SUA level showed that the control group<the SAP group<the UA group<the AMI group(P<0.05).ROC curves showed that CTRPI and SUA were effective indicators in the diagnosis of coronary heart disease(P<0.05),and the area under the curve of combined diagnosis of CTRPI and SUA was the largest.Comparison of CTRP1 level in patients with different lesion counts of coronary artery disease showed that three-vessel disease<doublevessel disease<single-vessel disease<the control group(P<0.05).Comparison of SUA level showed that threevessel disease>double-vessel disease>single-vessel disease>the control group(P<0.05).Conclusion Serum CTRP1 and SUA are related to coronary heart disease patients and the number of vascular lesions.CTRP1 combined with SUA has a higher diagnostic efficiency for coronary heart disease.