原发性闭角型青光眼发病机制研究进展

Progress in the pathogenesis of primary angle-closure glaucoma

原发性闭角型青光眼(PACG)在亚洲特别是中国发病率很高,严重困扰人民健康,是最为常见的一种青光眼类型。其主要特点是房角关闭,房水引流受阻,结果,眼压会升高,并伴随着特征性的视神经乳头凹陷及视野缺损的变化,两者都会随着病程逐渐扩大。研究证实,PACG的发病原因复杂,可能与诸多因素相关,包括异常的眼球解剖结构和许多促发因素。由于具体发病机制不明,PACG的防治面临诸多挑战。本文对近年来PACG发病机制的研究新进展进行了归纳总结,以期对临床工作提供指导作用。

Primary angle-closure glaucoma(PACG)has a high incidence in Asia,especially in China,which seriously plagues people’s health.It is the most common type of glaucoma and type.The main feature is that the angle of the anterior chamber is closed and the drainage of the aqueous humor is blocked.As a result,the intraocular pressure will increase,accompanied by the characteristic changes of the optic nerve head depression and visual field defects,both of which will gradually expand with the course of the disease.Studies have confirmed that the cause of PACG is complex and may be related to many factors,including abnormal eye anatomy and many triggering factors.Because the specific pathogenesis is unknown,the prevention and treatment of PACG faces many challenges.In this paper,the recent advances in the research on the pathogenesis of PACG have been summarized,in order to provide guidance for clinical work.