摘要
ABC转运蛋白(ATP-binding cassette transporter,ABC transporter)作为一种超大膜转运蛋白家族,在大多数生物体中发挥着重要作用。文中从结构特征、转运机制以及生理功能等方面论述了ABC转运蛋白的研究进展,进而着重综述了近些年来ABC转运蛋白在合成生物学领域中的应用,并为今后进一步的研究提出了展望,希望为扩展其应用提供指导。
As an ancient and huge family of membrane proteins, ATP-binding cassette transporter(ABC transporter) plays an important physiological role in most organisms. Herein, we introduce the research progress in ABC transporters on the aspects of structural characteristic, transport mechanism and physiological functions. We also focus on the application of ABC transporters in the field of synthetic biology in recent years. Finally, we propose future research needs.
作者
曲俊泽
陈天华
姚明东
王颖
肖文海
李炳志
Junze Qu;Tianhua Chen;Mingdong Yao;Ying Wang;Wenhai Xiao;Bingzhi Li(Frontier Science Center for Synthetic Biology,Key Laboratory of Systems Bioengineering(Ministry of Education),Tianjin University,Tianjin 300072,China;Frontier Technology Research Institute,Tianjin University,Tianjin 301700,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2020年第9期1754-1766,共13页
Chinese Journal of Biotechnology
基金
国家重点研发计划(No.2018YFA0900702)
天津市自然科学基金(No.17JCYBJC23900)资助。
关键词
膜转运蛋白
ABC转运蛋白
结构特征
转运机制
生理功能
membrane transport proteins
ABC transporters
structural characteristic
transport mechanism
physiological functions
