蒿芩清胆汤对湿瘀型盆腔炎性疾病后遗症患者血清TGF-β1及Smad3的影响

Effects of Haoqin Qingdan Decoction(蒿芩清胆汤)on Serum TGF-β1 and Smad3 in Patients with Sequela of Genital Pelvic Inflammatory Disease

目的:观察蒿芩清胆汤对湿瘀型盆腔炎性疾病后遗症患者血清TGF-β1及Smad3的影响。方法:将60例符合诊断标准的患者随机分为观察组和对照组,每组30例,分别采用蒿芩清胆汤、花红胶囊治疗,20 d后,观察两组的临床疗效,治疗前后局部症状与体征评分,并测定血清TGF-β1(转化生长因子)及Smad3(Smad蛋白)的表达。结果:观察组、对照组愈显率分别为66.7%、50.0%,总有效率分别为93.3%、83.3%;治疗后两组血清TGF-β1的表达均升高、Smad3的表达均降低,组间比较,差异有统计学意义(P<0.05)。结论:蒿芩清胆汤调节血清TGF-β1、Smad3的表达,减轻组织粘连及纤维化,因而治疗盆腔炎性疾病后遗症具有较好临床疗效。

Objective:To observe the effects of Haoqi Qingdan Decoction on serum TGF-β1 and Smad3 levels in patients with sequela of genital pelvic inflammatory disease belonging to dampness and stasis stagnation.Methods:Sixty patients with sequela of genital pelvic inflammatory disease were randomly divided into the observation group and the control group with each 30 cases,they were treated with Haoqi Qingdan Decoction and Huahong Capsules respectively.After treated 20 days,the clinical efficacy of the two groups was appraised and the serum TGF-β1 and Smad3 level s were detected by ELISA.Results:The cure rates of the observation group and control group were 66.7%and 50.0%respectively,the total effective rates were 93.3%and 83.3%;the expression of serum TGF-β1 was increased and the expression of Smad 3 was decreased after treatment,The difference was statistical significance between the two groups(P<0.05).Conclusion:Haoqi Qingdan Decoction has a good clinical effect on sequela of genital pelvic inflammatory disease,through regulating the expression of serum TGF-β1 and Smad3 reducing the tissue adhesion and fibrosis.