探讨艾滋病合并丙肝患者接受抗病毒治疗后对其CD4+T细胞数、HIV载量的影响

Research about the effect of antiviral treatment on CD4+T cell number and HIV loading in AIDS patients combined with hepatitis C

目的探究艾滋病合并丙肝患者接受抗病毒治疗后对其CD4+T细胞数、HIV数量的影响。方法对本院2017年1月到2019年1月间收治的艾滋病合并丙肝患者展开研究,80例HIV患者在2017年1月接受采用随机抽样法从中抽选出80例视为观察组,另选择同期接受治疗的单纯艾滋病患者作为对照组,所有患者均接受抗病毒治疗,比较2组患者进抗病毒治疗或CD4+T细胞数、HIV载量情况。结果接受抗病毒治疗前,观察组患者与对照组患者的CD4+T细胞数对比并无显著差异性:P>0.05。治疗后,两组患者的CD4+T细胞数均上升,但是观察组患者上升程度小于对照组,组间数据对比结果显示:P值<0.05。2组患者治疗前后HIV病毒载量对比均无统计学差异性:P>0.05。结论艾滋病合并丙肝患者在接受抗病毒治疗后,其CD4+T细胞数上升程度低于单纯艾滋病患者,艾滋病患者合并丙肝会进一步导致其免疫功能降低,而HIV载量则与患者是否合并丙肝并无较大关联。

Objective To explore the effect of antiviral treatment on CD4+T cells and HIV loading in AIDS patients combined with hepatitis C.Methods Patients with AIDS combined with hepatitis C admitted to our hospital from January 2017 to January 2019 were chosen as research subjects.80 HIV patients were selected randomly as observation group in January 2017,and other patients,who were diagnosed of pure AIDS and were treated at the same time,were selected as control group.All patients were treated with antiviral treatment.The number of CD4+T cells and HIV loading between the two groups were compared.Results Before antiviral treatment,there was no significant difference in the number of CD4+T cells between the observation group and the control group(P>0.05).After treatment,the number of CD4+T cells in the two groups increased,but the observation group increased less than the control group.(P<0.05).There was no significant difference in HIV loading between the two groups before and after treatment(P>0.05).Conclusions The number of CD4+T cells in patients with AIDS combined with hepatitis C is lower than that in patients with AIDS alone after antiviral treatment.The immune function of patients with AIDS combined with hepatitis C will be further reduced,while the HIV loading is not significantly related to whether patients get hepatitis C or not.