Amyloid beta在湿性年龄相关性黄斑变性患者中的表达及意义

Expression and Significance of Amyloid Beta in Patients with Wet Age-related Macular Degeneration

目的:探讨Amyloid beta(Aβ)在湿性年龄相关性黄斑变性患者中的表达及意义。方法:2017年9月到2019年5月选择在本院诊治的湿性年龄相关性黄斑变性患者72例(72眼),检测血清Aβ含量,调查患者的一般资料、临床特征并进行相关性分析。结果:在72例患者中,平均血清Aβ含量为203.29±14.29 ng/mL,其中Aβ含量≥180 ng/mL 40例。Aβ阳性组的脉络膜厚度显著高于Aβ阴性组(P<0.05)。Aβ阳性组的患眼动脉舒张末期血流速度和收缩期峰值血流速度都显著低于Aβ阴性组(P<0.05)。Aβ阳性组的的性别、年龄、眼压、血压、体重指数、病程等与Aβ阴性组对比差异无统计学意义(P>0.05)。直线相关性分析显示血清Aβ含量与脉络膜厚度、患眼动脉舒张末期血流速度和收缩期峰值血流速度都有显著相关性(P<0.05),其中Aβ含量与脉络膜厚度呈正相关(r=0.566,P=0.003),Aβ含量与患眼动脉舒张末期血流速度和收缩期峰值血流速度呈负相关(r=-0.673,P=0.000;r=-0.455,P=0.010)。结论:Aβ在湿性年龄相关性黄斑变性患者中多呈现高表达状况,血清Aβ含量与脉络膜厚度、患眼动脉舒张末期血流速度和收缩期峰值血流速度相关,从而影响患者病情的进展。

Objective:To explore the expression and significance of Amyloid beta(Aβ)in patients with wet age-related macular degeneration.Methods:From September 2017 to May 2019,72 patients(72 eyes)with wet age-related macular degeneration diagnosed and treated in our hospital were selected as the research subjects,the serum Aβcontent were detected,and the general information and clinical characteristics of patients were investigated and were given correlation analysis.Results:The average serum Aβcontent were in the 72 patients were 203.29±14.29 ng/mL,of which 40 patients were Aβcontent≥180 ng/mL.The choroid thickness of the Aβpositive group was significantly higher than that of the Aβnegative group(P<0.05).The end-diastolic blood flow velocity and peak systolic blood flow velocity in the Aβ-positive group were significantly lower than those in the Aβ-negative group(P<0.05).There were no significant difference in gender,age,intraocular pressure,blood pressure,body mass index,and duration of disease in the Aβ-positive group compared with the Aβ-negative group(P>0.05).Linear correlation analysis showed significant correlations between serum Aβcontent and choroid thickness,end-diastolic blood flow velocity,and peak systolic blood flow velocity of the affected ophthalmic artery(P<0.05).The Aβcontent was positively correlated with choroid thickness(r=0.566,P=0.003),and the Aβcontent was negatively correlated with the end-diastolic blood flow velocity and peak systolic blood flow velocity of the affected ophthalmic artery(r=-0.673,P=0.000;r=-0.455,P=0.010).Conclusion:Aβare highly expressed in patients with wet age-related macular degeneration.Serum Aβcontent are related to choroid thickness,affected end-diastolic blood flow velocity and peak systolic blood flow velocity,and thus affects the progression of patients.