羊布鲁氏菌病活疫苗(S2株)灌服免疫绵羊试验

Immunity Test of Live Brucellosis Vaccine(S2 strain)in Sheep

为了解羊布鲁氏菌病活疫苗(S2株)免疫效果和免疫副反应情况,为羊布病免疫和检疫提供参考依据,以科学开展布病防控工作。对本地布病抗体检测为阴性的绵羊灌服含100亿活菌的S2弱毒活疫苗,在免疫后第38、77天,用虎红平板凝集试验进行血清抗体检测,比对我市已完成的羊布鲁氏菌病活疫苗(M5株)免疫试验和甘肃省河西地区其他市州布病S2疫苗免疫结果,得出羊布病疫苗S2株免疫效果差于羊布病疫苗M5株,免疫副反应也较轻,但应注意免疫方式方法,开展S2苗灌服免疫,建议实施选择性免疫,不免老、弱、病、残、幼羊。目前来看,布病S2苗仍是国内羊免疫的首选疫苗。

To investigate the immune effects and side effects in sheep immunized with live Brucellosis vaccine(S2 strain),provide reference for immunization and quarantine of sheep Brucellosis,scientifically carry out prevention and control of brucellosis.Selecting native sheep negative for Brucellosis antibodies test,oral immunization of 10 billion CFU live Brucellosis vaccine(S2 strain),at the 38th and 77th day after immunization,the antibodies were detected by Rose Bengal plate agglutination test,compare the immunity test of live Brucellosis vaccine(M5 strain)in sheep that Jinchang city completed and the immune results of Brucellosis vaccine(S2 strain)in other cities in the west of Yellow River in Gansu Province.It is concluded that the immune effect of the sheep Brucellosis vaccine(S2 strain)is worse than the sheep Brucellosis vaccine(M5 strain),at the same time,the immune side effects are lighter,however,when carrying out live Brucellosis vaccine(S2 strain)immunization,attention should be paid to immunization methods,recommended for selective immunization,don't immune old,weak,sick,disabled,young sheep.For now,Brucellosis vaccine(S2 strain)remains the first choice for sheep immunization in China.