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心血管健康行为对单纯舒张期高血压治疗作用分析

Analysis on therapeutic effects of cardiovascular health behavior on isolated diastolic hypertension
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摘要 (1)目的研究心血管健康(cardiovascular health,CVH)行为对单纯舒张期高血压的治疗作用。(2)方法连续选择唐山工人医院心内科就诊未经系统治疗的单纯舒张期高血压(舒张压≥90 mmHg,收缩压<140mmHg)患者500例。随机分为CVH行为强化治疗+降压药物治疗组246例(强化组),CVH行为治疗+降压药物治疗组254例(对照组),利用前瞻性研究方法,中位数随访1年,分析CVH行为对单纯舒张期高血压的治疗作用。(3)结果 CVH行为强化组中失访2例,最终纳入研究244例[男210例,年龄(36.52±5.32)岁],对照组失访16例,纳入研究238例[男203例,年龄(35.77±5.08)岁]。强化治疗组与对照组在性别、年龄、CVH行为评分、吸烟、体质量指数(BMI)、体育锻炼、健康饮食、收缩压(SBP)、舒张压(DBP)、服用降压药物、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL)、空腹血糖、冠心病病史、糖尿病病史、高脂血症病史、高敏C-反应蛋白(Hs-CRP)、同型半胱氨酸(Hcy)比较,差异无统计学意义(P>0.05);总胆固醇(TC),甘油三酯(TG)、尿酸(UA)比较,差异有统计学意义(P<0.05);基线CVH行为评分强化组(3.65±2.47)分,对照组(3.49±2.46)分,差异无统计学意义(P=0.48);中位数随访1年,CVH行为评分强化组(6.06±0.92)分,对照组(4.06±1.24)分,CVH行为强化治疗组健康评分明显增加,差异有统计学意义(P=0.00);基线CVH行为强化组舒张压(97.85±8.17)mmHg,对照组(97.37±7.62)mmHg,差异无统计学意义(P=0.49);中位数随访1年,CVH行为评分强化组舒张压(84.9±3.94)mmHg,对照组(90.19±4.49)mmHg,CVH行为强化组舒张压降低明显低于对照组,差异有统计学意义(P=0.00)。(4)结论心血管健康行为有助于控制单纯舒张期高血压。 Objective To study the effect of cardiovascular health(CVH)behavior on diastolic hypertension.Methods 500 patients with diastolic hypertension(diastolic pressure≥90 mmHg,systolic pressure<140 mmHg)were selected from the Department of Cardiology of Tangshan workers'hospital.They were randomly divided into two groups:the CVH behavior intensive therapy+antihypertensive drug therapy group(246 people),the CVH behavior therapy+antihypertensive drug therapy group(254 cases)(control group).Using prospective research method,the median follow-up was 1 year,and the therapeutic effect of CVH behavior on simple diastolic hypertension was analyzed.Results In the CVH behavior enhancement group,2 cases were lost,244 Cases(210 males,age 36.52±5.32 years old)were included in the study,16 cases in the control group,238 cases(203 males,age 35.77±5.08 years old)were included in the study.In the intensive treatment group and the control group,gender,age,CVH behavior score,smoking,body mass index(BMI),physical exercise,healthy diet,SBP,DBP,antihypertensive drugs,LDL,HDL,FBG,CHD,DM,HDL,HSC-There was no significant difference between hs CRP and Hcy(P>0.05);there was significant difference between TC,TG and UA(P<0.05).There was no significant difference(P=0.48)in the baseline CVH behavior score enhancement group(3.65±2.47)and the control group(3.49±2.46);after a median follow-up of 1 year,the CVH behavior score enhancement group(6.06±0.92)and the control group(4.06±1.24),the health score of the CVH behavior enhancement treatment group increased significantly(P=0.00);the diastolic pressure of the baseline CVH behavior enhancement group was 97.85±8.17mmhg,and the control group(P=0.00)There was no significant difference(P=0.49)between the two groups(97.37±7.62)mmhg;the median follow-up for one year showed that the diastolic blood pressure in the CVH behavior score enhanced group was(84.9±3.94)mmhg,and that in the control group was(90.19±4.49)mmhg.The diastolic blood pressure in the CVH behavior enhanced group was significantly lower than that in the control group(P=0.00).Conclusion Cardiovascular health behavior is helpful to control simple diastolic hypertension.
作者 郁静 韩全乐 岳博成 张沛 宋丽华 吴寿岭 姚绍鑫 YU Jing;HAN Quanle;YUE Bocheng(Department of Intervention,Tangshan Gongren Hospital,Tangshan 063000,China)
出处 《华北理工大学学报(医学版)》 2020年第6期462-467,共6页 Journal of North China University of Science and Technology:Health Sciences Edition
基金 河北省重点科技研究计划(编号:20181284)。
关键词 心血管健康行为 单纯舒张期高血压 前瞻性研究 Cardiovascular health behaviors Isolated diastolic hypertension Prospective study
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