长春西汀注射液治疗急性脑梗死患者的临床研究

Clinical study of vinpocetine injection in the treatment of patients with acute cerebral infarction

目的观察长春西汀治疗急性脑梗死(ACI)的临床疗效和安全性。方法将102例ACI患者随机分为试验组(n=51)和对照组(n=51)。对照组予以口服瑞舒伐他汀钙片20 mg和静脉滴注丁苯酞100 mL,每日1次。试验组在对照组基础上予以静脉滴注长春西汀20 mg,每日1次。2组均治疗2周。比较2组的临床疗效、局部脑血流量(rCBF)、血液流变学指标和药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为94.12%(48例/51例)和80.39%(41例/51例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的rCBF为(19.52±2.51),(13.06±1.64)mL·100(g·min^-1),全血高切粘度为(3.84±0.74),(4.15±0.66)mPa·S,全血低切粘度为(11.74±1.65),(14.23±2.38)mPa·S,纤维蛋白原为(1.25±0.22),(2.96±0.43)g·L^-1,差异均有统计学意义(均P<0.05)。试验组出现发热、恶心呕吐,药物不良反应发生率为9.80%(5例/51例);对照组患者发生恶心呕吐、过敏反应、发热,药物不良反应发生率为11.76%(6例/51例),2组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论常规治疗基础上予以长春西汀对ACI患者进行治疗,可显著改善其rCBF和血液流变学指标,安全性好。

Objective To investigate the cliniacl efficacy and safety of vinpocetine in patients with acute cerebral infarction(ACI).Methods 102 patients with ACI were randomly assigned to the treatment group(n=51),the control group(n=51).The control group was given 20 mg of rosuvastatin calcium tablets orally,100 mL of butylphthalide intravenous drip once daily.On this basis,the treatment group was given vinpocetine intravenous drip,20 mg once daily.Both groups were treated for 2 weeks.Clinical efficacy,regional cerebral blood flow(rCBF),hemorheological indexes and adverse reactions were compared between the two groups.Results The total effective rates of the treatment group and the control group were 94.12%(48 cases/51 cases)and 80.39%(41 cases/51 cases)(P<0.05).After treatment,the rCBF of treatment group and control group was(19.52±2.51)and(13.06±1.64)mL·100(g·min)^-1,the whole blood high shear viscosity was(3.84±0.74)and(4.15±0.66)mPa·S,the whole blood low shear viscosity was(11.74±1.65)and(14.23±2.38)mPa·S,and fibrinogen was(1.25±0.22)and(2.96±0.43)g·L^-1.There were statistically significant differences between the treatment group and the control group in the above indicators(P<0.05).The incidence of adverse drug reactions was 9.80%(5 cases/51 cases)in the experimental group;the incidence of adverse drug reactions was 11.76%(6 cases/51 cases)in the control group,and the difference was not statistically significant(P>0.05).Conclusion Vinpocetine on the basis of conventional treatment can safely improve rCBF and hemorheology indexes in patients with ACI.