补肾活血法对慢性阻塞性肺疾病急性加重期合并肺栓塞患者的临床疗效研究

Clinical study on the treatment of acute exacerbation of COPD with pulmonary embolism by invigorating the kidney and activating blood circulation

目的探讨补肾活血法治疗慢性阻塞性肺疾病加重期合并肺栓塞患者的临床效果。方法回顾性分析2016年1月—2019年12月我院收治的60例慢性阻塞性肺疾病急性加重期合并肺栓塞患者的临床资料,按治疗方法的不同分为对照组(川芎嗪注射液,30例)和观察组(补肾活血法,30例),对比2组肺功能和炎症因子指标。结果治疗前,2组FEV1、FVC、FEV1/FVC比较,差异无统计学意义(P>0.05);治疗后,2组FVC、FEV1、FEV1/FVC均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,2组血清TNF-α、IL-8、IL-6比较,差异无统计学意义(P>0.05);治疗后,2组血清IL-8、IL-6、TNF-α均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病急性加重期合并肺栓塞患者,采用补肾活血法治疗可降低对肺功能的损伤和炎症因子反应,促进恢复。

Objective To explore the clinical effect of invigorating the kidney and activating blood circulation in the treatment of COPD with pulmonary embolism.Methods the clinical data of 60 patients with acute exacerbation of COPD and pulmonary embolism admitted to our hospital from January 2016 to December 2019 were analyzed retrospectively.According to the different treatment methods,they were divided into control group(ligustrazine injection,30 cases)and observation group(kidney nourishing and blood activating method,30 cases).The pulmonary function and inflammatory factor indexes of the two groups were compared.Results Before the treatment,there was no significant difference in FEV1,FVC and FEV1/FVC between the two groups(P>0.05);after the treatment,FVC and FEV1/FVC of the two groups were higher than before the treatment,the difference was statistically significant(P<0.05);after the treatment,FVC and FEV1/FVC were higher than the control group,the difference was statistically significant(P<0.05);before the treatment,there was no difference in serum TNF-α,IL-8 and IL-6 between the two groups After treatment,the levels of IL-8,IL-6 and TNF-αin serum of the two groups were lower than those before treatment(P<0.05);after treatment,the levels of IL-8,IL-6 and TNF-α in serum of the observation group were lower than those of the control group(P<0.05).Conclusion in the treatment of acute exacerbation of COPD with pulmonary embolism,the method of invigorating kidney and activating blood circulation can reduce the damage of renal function and the reaction of inflammatory factors,and promote the recovery of patients.