药物性牙龈肥大的病因研究及治疗进展

Etiology and progress in the therapy of drug-induced gingival enlargement

药物性牙龈肥大(DIGE)是指长期服用某些药物而引起的牙龈纤维性增生和体积增大,严重危害患者的口腔健康。DIGE的病因尚未明确,治疗较为棘手。本文从炎症、Wnt/β-catenin信号通路、上皮间充质转化、整合素、基质金属蛋白酶等5个方面综述了DIGE病因学的研究进展,并从非手术治疗、手术治疗、药物治疗和辅助治疗等方面对其治疗方法的研究进展进行总结,以期对后续的研究及治疗提供一定的参考。

Drug-induced gingival enlargement (DIGE) refers to gingival fibrosis hyperplasia and volume enlargement caused by long-term use of certain drugs.DIGE can cause serious damage to the oral health of patients.Its etiology is unclear,and treatment is difficult.This article will discuss the research progress of the etiology of DIGE from five aspects:inflammation,the Wnt/β-catenin signaling pathway,epithelial-mesenchymal transition,integrin,and matrix metalloproteinase.Therapeutic progress is reviewed from four aspects of non-surgical treatment,surgical treatment,drug therapy and adjuvant therapy to provide a certain reference value for subsequent research and treatment.