药物相关性颌骨坏死发病机制的研究进展

Research progress on the pathogenesis of medication-related osteonecrosis of the jaw

药物相关性颌骨坏死(MRONJ)是一种只发生于颌骨的严重疾病,其发生与抗骨吸收药物和抗血管生成药物有关,如双膦酸盐、狄诺塞麦等。目前临床上缺乏有效的治疗手段。近年来,有关MRONJ发病机制的研究进展非常迅速,但是确切机制尚不清楚。目前有关MRONJ发生机制的主要假说包括骨重建抑制、血管生成抑制、口腔内微生物感染、免疫抑制等学说,还有软组织毒性、颌骨微裂纹等,且其发病可能是多因素协同作用的结果。本文就MRONJ发病机制的研究进展进行综述,以期为进一步的深入研究提供帮助。

Medication-related osteonecrosis of the jaw(MRONJ)is a severe bone disease unique to the jaw.It is closely related to antiresorptive drugs and antiangiogenic drugs,such as bisphosphonates and denosumab.The effect of current treatments on MRONJ is limited.Despite the rapid progression of the pathogenesis of MRONJ,the specific mechanism remains unclear.The hypotheses of MRONJ mainly include disrupted bone remodeling,suppression of angiogenesis,oral microbial infection,inhibition of immunity,toxicity of soft tissue,and microcracks.The pathogenesis of MRONJ may be influenced by multiple factors.The purpose of the current review is to summarize recent progress on MRONJ research.