丁二磺酸腺苷蛋氨酸治疗乙型肝炎病毒性肝硬化合并胆汁瘀积的效果观察

Effect of ademetionine on HBV-infected liver cirrhosis with cholestasis

目的探讨丁二磺酸腺苷蛋氨酸治疗乙型肝炎病毒性(HBV)性肝硬化合并胆汁瘀积的效果。方法抽取南阳市中心医院2018年1月至2019年1月收治的120例HBV感染肝硬化合并胆汁瘀积患者,采用随机数字表分组法分为观察组(59例)与对照组(61例),观察组在常规保肝药物的基础上给予丁二磺酸腺苷蛋氨酸治疗,对照组给予常规保肝药治疗。对比两组治疗前后肝功能、血清肿瘤坏死因子α(TNF-α)、白细胞介素-12 (IL-12)水平和不良反应。对比两组患者临床疗效。结果治疗6周,观察组丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、天门冬氨酸氨基转移酶(AST)低于对照组,白蛋白(ALB)高于对照组,差异有统计学意义(P<0.05)。治疗6周,观察组血清TNF-α、IL-12水平低于对照组,差异有统计学意义(P<0.05);治疗6周,观察组不良反应发生率(11.86%)低于对照组(21.31%),差异未见统计学意义(P>0.05)。治疗6周,观察组总有效率(81.35%)高于对照组(52.45%),差异有统计学意义(P<0.05)。结论丁二磺酸腺苷蛋氨酸治疗HBV感染肝硬化合并胆汁瘀积的疗效较好,可以有效改善肝功能和血清TNF-α、IL-12水平,降低不良反应发生率。

Objective To investigate the effect of ademetionine on HBV-infected liver cirrhosis with cholestasis.Methods One hundred and twenty patients with HBV-infected liver cirrhosis combined with cholestasis admitted to Nanyang Central Hospital from January 2018 to January 2019 were divided into the observation group(59 cases)and the control group(61 cases)by random number table.The control group received conventional hepatoprotective drugs,and the observation group received ademetionine on the basis of conventional hepatoprotective drugs.The liver function,serum Tumor necrosis factorα(TNF-α),interleukin-12(IL-12)levels and adverse reactions as well as clinical efficacy were compared between the two groups before and after treatment.Results After 6 weeks of treatment,the alanine aminotransferase(ALT),total bilirubin(TBIL),alanine aminotransferase(AST)in the observation group were significantly lower than those in the control group,while the albumin(ALB)was higher than those in the control group,the differences were significant(P<0.05).After 6 weeks of treatment,the serum levels of TNF and IL-12 in the observation group were lower than those in the control group,the differences were significant(P<0.05).After 6 weeks of treatment,the incidence of adverse reactions in the observation group(11.86%)was lower than that in the control group(21.31%),and the difference was not significant(P>0.05).After 6 weeks of treatment,the total effective rate of the observation group(81.35%)was higher than that of the control group(52.45%),the difference was significant(P<0.05).Conclusions Ademetionine has a good curative effect on HBV-infected liver cirrhosis with cholestasis,which can effectively improve liver function and serum TNF-α,IL-12 levels,and reduce the incidence of adverse reactions.