雌孕激素序贯联合坤泰胶囊对卵巢早衰的疗效及其对患者卵巢血流动力学指标的影响

Effect of sequential combination of estrogen and progesterone combined with kuntai capsule on premature ovarian failure and their influence on ovarian hemodynamic indexes of patients

目的分析雌孕激素序贯联合坤泰胶囊对卵巢早衰(POF)的疗效及其对患者卵巢血流动力学指标的影响。方法抽取2017年12月至2019年12月于郑州颐和医院治疗的POF患者102例,按照数字表法将其分为观察组和对照组,每组51例。对照组行雌孕激素序贯治疗,观察组在对照组基础上加服坤泰胶囊;观察两组患者临床疗效、卵巢血流动力学指标、血清雌激素、抗苗勒氏管激素(AMH)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、抑制素B(INHB)含量等变化状况。结果观察组患者有效率为94.12%,高于对照组的80.39%(P<0.05);治疗后两组患者血清雌二醇(E2)含量较治疗前升高,促黄体生成素(LH)、促卵泡生成素(FSH)含量较治疗前降低;治疗后观察组LH含量低于对照组(P<0.05);治疗后观察组患者血流阻力指数(RI)、搏动指数(PI)较同组治疗前、对照组治疗后降低,动脉收缩期最大流速(PSV)较同组治疗前、对照组治疗后升高(P<0.05);治疗后观察组患者血清AMH含量、AFC数量及子宫内膜厚度较同组治疗前、对照组治疗后升高(P<0.05);治疗后观察组患者血清VEGF、bFGF及INHB含量较同组治疗前、对照组治疗后升高(P<0.05)。结论雌孕激素序贯联合坤泰胶囊对POF疗效理想,可改善患者血清AMH与雌激素含量,提高卵巢储备功能,改善卵巢血运。

Objective To analyze the effect of sequential combination of estrogen and progesterone with kuntai capsule on patients with premature ovarian failure(POF)and their influence on ovarian hemodynamics of patients.Methods A total of 102 patients with POF treated in Zhengzhou Yihe Hospital from December 2017 to December 2019 were selected,they were divided into observation group and control group according to the digital table method,51 cases in each group.The control group received estrogen and progesterone sequential treatment,and the observation group took kuntai capsule on the basis of the control group.The clinical efficacy,ovarian hemodynamic indexes,serum estrogen,anti Mullerian hormone(AMH),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)and inhibin B(inhb)levels in the two groups were observed.Results The effective rate of patients in the observation group was 94.12%,which was higher than 80.39%in the control group(P<0.05);after treatment,the serum estradiol(E2)content of the two groups of patients was higher than that before treatment,and the levels of luteinizing hormone(LH),follicle stimulating hormone(FSH)were lower than those before treatment;the content of LH in the observation group was lower than that in the control group after treatment(P<0.05);after treatment,the blood flow resistance index(RI)and pulsatility index(PI)in the observation group were lower than those before treatment and those in the control group after treatment,and the maximum systolic velocity(PSV)in the observation group was higher than that before treatment and that in the control group after treatment(P<0.05);the serum AMH content of the observation group after treatment,AFC quantity and endometrial thickness were higher than those before treatment and those in the control group(P<0.05);after treatment,the levels of serum AMH,AFC and endometrial thickness in the observation group were higher than those before treatment and those in the control group after treatment P<0.05);after treatment,the levels of serum VEGF,bFGF and INHB in the observation group were higher than those before treatment andthose in the control group after treatment(P<0.05).Conclusions Sequential estrogen and progesterone combined with kuntai capsule has ideal curative effect on patients with POF,which can improve serum AMH and estrogen content,improve ovarian reserve function and ovarian blood supply.