摘要
基质金属蛋白酶(MMP)是一大类蛋白酶,可切割或重塑细胞外基质(ECM)和细胞表面蛋白。MMP的活性受到多种细胞因子的调节,包括金属蛋白酶组织抑制因子(TIMP)、信号转导分子和细胞黏附分子等。最新的研究表明,MMP在许多急性和慢性肾病的病理生理过程中都有作用。本文就MMP的分类、在肾脏中的表达与分布及其在肾移植相关损伤中的作用作一综述。
Matrix metalloproteinase(MMP)is a large class of proteases which can cut or reshape extracellular matrix(ECM)and cell surface proteins.The activity of MMP is regulated by a variety of cytokines,including tissue inhibitor of metalloprotease(TIMP),signal transduction molecules and cell adhesion molecules.The latest research shows that MMP has a role in the pathophysiology process of many acute and chronic kidney diseases.In this article,the classification,expression and distribution in the kidney of MMP and its role in injury related renal transplantation was reviewed.
作者
董岩
赵弘
满江位
杨立
Dong Yan;Zhao Hong;Man Jiangwei;Yang Li(Department of Urology,Lanzhou University Second Hospital,Lanzhou 730030,China)
出处
《器官移植》
CAS
CSCD
北大核心
2020年第6期760-764,共5页
Organ Transplantation
基金
甘肃省自然科学基金项目(17JR5RA237)。
关键词
基质金属蛋白酶
肾移植
细胞外基质
金属蛋白酶组织抑制因子
急性肾损伤
缺血-再灌注损伤
慢性移植肾肾病
炎症反应
Matrix metalloproteinase
Renal transplantation
Extracellular matrix
Tissue inhibitor of metalloprotease
Acute kidney injury
Ischemia-reperfusion injury
Chronic allograft nephropathy
Inflammation
