Fractalkine/CX3CR1信号轴在炎症疾病中的研究进展

Advances in study of Fractalkine/CX3CR1 signal axis in inflammatory diseases

不规则趋化因子Fractalkine(FKN)是CX3C家族的唯一成员,FKN与其独有的受体CX3CR1结合后可以作为一种转运介质介导巨噬细胞、淋巴细胞、DC细胞以及NK细胞等的迁移,促进其发挥抗原呈递、吞噬、杀伤和免疫调节等重要生物学作用。近年来研究表明FKN/CX3CR1参与多种疾病的发生发展。本文主要探讨FKN/CX3CR1信号轴在类风湿关节炎、神经系统炎症、动脉粥样硬化、脓毒症等炎症疾病中的作用。

Irregular chemokine Fractalkine(FKN) is the only member of CX3C family.FKN,when combined with its unique receptor CX3CR1,can be used as a transport medium to mediated macrophages,lymphocytes,DC cells and NK cells to play important biological roles such as antigen presentation,phagocytosis,killing and immune regulation.Recent studies have shown that FKN/CX3CR1 participate in the occurrence and development of many diseases.This article mainly discusses the role of FKN/CX3CR1 signal axis in inflammatory diseases such as rheumatoid arthritis,nervous system inflammation,atherosclerosis,sepsis,etc.