射血分数保留性心力衰竭动物模型的研究进展

Animal Models of Heart Failure with Preserved Ejection Fraction

近年来,射血分数保留性心力衰竭(HFpEF)成为严重威胁人类健康的重要疾病.HFpEF患者约占总心力衰竭人数的50%以上,且病死率高,预后差.目前关于HFpEF的机制并不清楚,且缺乏有效的治疗药物.对HFpEF病理生理机制的理解既受到人体心肌活检的限制,也受到缺乏完整模拟人类病理的动物模型的限制.因此,建立合适的动物模型有助于深入了解HFpEF的病理生理机制及分子信号通路,并为潜在治疗的临床前研究提供新思路.现综述目前可用于研究HFpEF的动物模型及其优缺点.

In recent years,heart failure with preserved ejection fraction(HFpEF)has become an important issue that poses a serious threat to human health.HFpEF patients account for more than 50%of the total number of heart failure patients,with high mortality and poor prognosis.At present,the mechanism of HFpEF is not clear,and there are no effective treatment drugs.Understanding the pathophysiology of HFpEF has been restricted both by human myocardial biopsies and by the lack of animal models that fully mimic human pathology.Therefore,the establishment of appropriate animal models can help us understand the pathophysiology mechanism and molecular signaling pathway of HFpEF,and provide new ideas for the preclinical investigation of potential therapies.In this review,we will provide an overview of the currently available models to study HFpEF as well as present advantages and disadvantages of these models.