埃谱利诺菌素浇泼剂对牦牛消化道线虫驱虫效力的研究

Study on the Efficacy of Eprinometin Pour on against Gastrointestinal Nematodes in Yaks

为评价埃谱利诺菌素浇泼剂对牦牛消化道线虫驱虫效力,选择1.5岁自然感染消化道线虫的牦牛100头,随机分为5组,每组20头,1~3组分别为埃谱利诺菌素浇泼剂0.4,0.5和0.6 mg/kg.b w组,沿背部皮肤中线浇注给药,4组为埃谱利诺菌素注射剂药物对照组,按0.2 mg/kg剂量颈部皮下注射,5组为阳性对照组,不给药。结果:1.埃谱利诺菌浇泼剂0.5 mg/kg剂量对消化道线虫(除毛首线虫外)的虫卵转阴率、减少率分别达90.0%和97.2%;对线虫的总计驱虫率达96.8%。2.0.6mg/kg剂量对消化道线虫(除毛首线虫外)的虫卵转阴率,减少率均达100.0%;对线虫的总计驱虫率达98.8%。3.0.4 mg/kg剂量对线虫虫卵的转阴率、减少率、驱虫率均低于0.5,0.6mg/kg剂量组。4.对照药物埃谱利诺菌素注射剂0.2 mg/kg剂量组对线虫的驱虫效果与埃谱利诺菌素浇泼剂0.5 mg/kg剂量组无显著差异。5.埃谱利诺菌浇泼剂3个剂量组试验牦牛未见异常反应。试验证明埃谱利诺菌浇泼剂0.4、0.5,0.6 mg/kg体重剂量驱除牦牛消化道线虫安全有效。其中以0.5 mg/kg剂量高效安全低残留。

One hundred yaks atabout1.5 years old with naturally infected gastrointestinal nematodeswere selected and randomly allocated into 5 groups with 20 yaks in each group. Yaks in group1-3 were poured-on with eprinomectin at a dose of 0.4,0.5 and 0.6 mg/kg bw respectively. Group 4 was used as drug control, in which yaks were subcutaneously injected with eprinomectin at 0.2 mg/kg dose.Group5 was used as the positive control group without treatment.The result showed:that1.In group 2(0.5 mg/kg), the percentage of yaks with noeggs, reduction percentage of nematode eggs and reduction percentage of nematodeswere 90.0%,97.2%and96.8%, respectively.2.In group 3(0.6 mg/kg),the above values were 100%, 100% and 99.1%, respectively.3.In group 1(0.4 mg/kg),these values were lower than those in group 2 and group 3.4.Similar results were obtained in group 4 as group 2. 5.No abnormal response was observed in all treated animals, showing the safety of the eprinomectin pour-on formulation.