B细胞激活因子在牙周炎发生发展中的作用

Role of B cell activating factor in the development of periodontitis

B细胞激活因子(B cell activating factor,BAFF)为B细胞的关键调节因子,针对BAFF的调控被认为是治疗多种免疫炎症性疾病的潜在靶标。牙周炎可促进局部和全身BAFF因子表达,同时BAFF已被证实能够加重牙周炎B细胞免疫反应和组织破坏过程。此外,BAFF还可激发CD4^+T细胞免疫反应,并抑制调节性T细胞和M2型巨噬细胞免疫反应,进而改变多种免疫炎症性疾病的发病过程。然而,上述生物学效应是否为BAFF加重牙周炎的重要原因仍缺乏直接证据,亟待开展相关研究予以证实。本文将就BAFF在牙周炎发生和进展中的表达及作用进行综述,旨在为开展BAFF牙周致病机制研究提供理论依据。

B cell activating factor(BAFF)is the key regulator of B cells and is considered as a potential therapeutic target for immune inflammatory diseases.Periodontitis can promote local and systemic BAFF factor expression,whereas BAFF aggravates B cell immune responses and tissue destruction in periodontitis.In addition,BAFF also stimulates CD4^+T cell response and inhibits regulatory T cell and M2 macrophage responses,thus changing the pathogenesis of a variety of immune inflammatory diseases.However,whether the biological effect mentioned above is an important mech-anism by which BAFF aggravates periodontitis still lacks direct evidence and should be confirmed in future research.To provide a theoretical basis for the study of the pathogenic mechanism of BAFF,the expression and role of BAFF in periodontitis is reviewed in this article.