专利视角下丙肝相关研究发展态势剖析

Analysis of the Development Trend of Hepatitis C Research Field from the Perspective of Patent

曾对患者的健康和生命造成极大危害的丙型病毒性肝炎近几年已逐步进入治愈时代,中国市场已成为制药巨头谋求业绩增长的新大陆且竞争愈演愈烈。本文基于专利分析视角,采集德温特数据库(Derwent Innovation)分析平台收录的1998—2018年国内外丙肝相关研究领域专利数据,综合运用文献计量和可视化方法分析丙肝相关研究全球专利申请时间趋势、地域分布、重要研发机构及其重点布局方向;同时结合产业和市场信息,分析丙肝治疗的明星药品、机构协同创新情况及演变趋势等,以期为我国在该领域的研究和产业发展提供参考。分析结果表明,近二十多年来,丙肝领域专利机构非常重视国际申请和协同合作;美国在该方面的研发实力走在世界前列,特别是一些跨国药企拥有多个可以达到治愈效果的口服药品且已进入中国市场甚至获得医保纳入资格,本土药企已经面临严重威胁。建议本土药企及科研机构可以考虑细化和深化研究主题、尝试根据市场需求调整研究方向、扩展研究领域关注相近疾病,以及加强竞争情报工作建设以便及时调整研发和市场策略,更好地应对未来我国丙肝市场逐渐萎缩的现实情况。

In recent years,hepatitis C could be cured though it had caused great harm to the health and life of patients in the past.Chinese market is becoming a new continent of opportunity for pharmaceutical giants to seek performance growth,and the competition is intensifying.This study attempts to explore the development trends of global technology on HCV from the perspective of patent and market,aiming to provide reference for future development in China.Based on the patent data from 1998 to 2018 at home and abroad in the Derwent Innovation(DI)platform,the paper comprehensively uses bibliometric and visualization methods to implement quantitative statistical analysis of the application year,country,important institutions and their R&D layout,and qualitatively analyzes the famous therapeutic drugs and evolution of institutional collaborative innovation combined with industry and market information.The results show that in the past two decades,patentees of the hepatitis C field have attached great importance to international applications and collaborative innovation;the United States is in the forefront of research and development in this area and many multinational pharmaceutical companies have a number of oral medicines that can achieve a curative effect;Chinese local pharmaceutical companies have faced serious threats.It is suggested that local pharmaceutical companies and research institutions should consider refining and deepening their research theme,try to adjust the research direction according to market demand,expand the research field to similar diseases,and strengthen the construction of competitive intelligence to adjust R&D and market strategies in a timely manner to better cope with the reality of the gradual shrinkage of China’s hepatitis C market in the future.