初诊2型糖尿病患者服药依从性动态变化趋势及纵向预测因素

Dynamic Change of Medication Compliance of Newly-diagnosed Patients with Type 2 Diabetes Mellitus and Its Longitudinal Predictors

目的分析初诊2型糖尿病患者服药依从性的动态变化趋势及其纵向的预测因素。方法以100例新确诊2型糖尿病患者为目标人群,利用糖尿病心理痛苦量表、用药信念量表、家庭关怀度指数问卷、Morisky药物依从性量表对患者进行资料收集;采用多元线性回归分析探讨确诊后第1天的糖尿病心理痛苦、用药信念、家庭关怀度对初诊2型糖尿病患者确诊后1、3及6个月的服药依从性影响。结果初诊2型糖尿病患者的服药依从性得分情况在确诊后1、3、6个月分别是(6.5±1.9)、(5.6±1.7)、(4.9±1.3)分;服药依从性呈动态下降趋势(P<0.05)。多元线性回归分析发现糖尿病心理痛苦程度对初诊2型糖尿病患者确诊1、3、6个月后服药依从性情况具有负向预测作用(P<0.05);用药信念对初诊2型糖尿病患者确诊1、3、6个月后服药依从性情况具有正向预测作用(P<0.05);家庭关怀度对初诊2型糖尿病患者确诊3、6个月后服药依从性情况具有正向预测作用(P<0.05)。结论2型糖尿病患者在初诊半年内服药依从性情况总体呈现动态下降的趋势,糖尿病心理痛苦、用药信念和家庭功能均可在早期预测初诊2型糖尿病患者的服药依从性情况。

Objective To analyze the dynamic change of medication compliance of newly-diagnosed patients with type 2 diabetes mellitus(T2DM)and its longitudinal predictors.Methods Totally 100 newly-diagnosed T2DM patients were surveyed by using Diabetes Distress Scale(DDS),the Beliefs About Medicine Questionnaire(BMQ),the Family APGAR(adaptation,partnership,growth,affection,resolve)index and Morisky Medication Adherence Scale(MMAS).Multiple linear regression was used to analyze the influence of diabetes distress,medication belief,and family care on medication compliance in the very day after the diagnosis,1 month,3 and 6 months after the diagnosis.Results The score of medication compliance 1 month,3 and 6 months after the diagnosis was 6.5±1.9,5.6±1.7 and 4.9±1.3 respectively,which was decreased dynamically(P<0.05).Multiple linear regression showed that diabetes distress was a negative predictor(P<0.05)but medication belief and family care were positive predictors(P<0.05)for medication compliance 1 month,3 and 6 months after the diagnosis.Conclusion Overall,T2DM patients demonstrate a dynamic decrease in terms of medication compliance in the first half year after the diagnosis and diabetes distress,medication belief,and family care are predictors for medication compliance in T2DM patients.