帕瑞昔布与氟比洛芬酯用于下肢骨折术后镇痛效果的比较

Comparison of Analgesic Effect of Parexib and Flurbiprofen on Lower Limb Fracture

目的对比帕瑞昔布与氟比洛芬酯用于下肢骨折术后镇痛效果。方法选取笔者医院接受治疗的下肢骨折患者60例,采用随机对照组法将患者分为帕瑞昔布(A组)和氟比洛芬酯(B组)各30例。A组患者静脉滴注帕瑞昔布,B组患者静脉滴注氟比洛芬酯,两组患者均持续治疗72h。对比两组患者的VAS、Ramsay评分、围术期DBP、SBP和MAP水平及不良心血管事件发生情况。结果治疗后,术后12、24h两组患者VAS比较,差异无统计学意义(P>0.05),术后48、72h A组VAS明显低于B组(P<0.05);术后12h两组患者Ramsay评分比较差异无统计学意义(P>0.05),术后24、48、72h A组Ramsay评分明显低于B组(P<0.05);A组患者在围术期DBP、SBP和MAP水平低于B组,但两组比较差异无统计学意义(P>0.05);A组不良反应发生率明显低于B组(P<0.05)。结论相比于氟比洛芬酯,帕瑞昔布用于下肢骨折术后疼痛作用具有较好的临床疗效,能改善围术期血流动力学,缓解疼痛,值得在临床上推广应用。

Objective To compare the analgesic effect of parexib and flurbiprofen on lower limb fractures.Methods Sixty patients with lower limb fractures were selected for treatment in our hospital,and the patients were divided into parexib(group A)and flurbiprofen(group B)by the random control method.Patients in group A received intravenous infusion of parecoxib,and patients in group B received intravenous infusion of flurbiprofen ester.Patients in both groups continued treatment for 72 hours.VAS,Ramsay scores,perioperative DBP,SBP and MAP levels and adverse cardiovascular events were compared between the two groups.Results After treatment,there was no statistically significant difference in VAS scores between the two groups at 12h and 24h after surgery(P>0.05),and VAS scores of the 48h and 72h groups were significantly lower than those of the B group(P<0.05).There was no statistically significant difference in Ramsay score between the two groups at 12h after surgery(P>0.05),and Ramsay score of the 24h,48h and 72ha groups was significantly lower than that of the B group(P<0.05).The perioperative levels of DBP,SBP and MAP in group A were lower than those in group B,but there was no statistical difference between the two groups(P>0.05).The incidence of adverse reactions in group A was significantly lower than that in group B(P<0.05).Conclusion Compared with flurbiprofen,parexib has better clinical efficacy in treating postoperative pain of lower limb fractures,improving hemodynamics and relieving pain during perioperative period,and is worthy of clinical application.